Assessment of Cytotoxic Activity of Rosemary (Rosmarinus officinalis L.)‎, Turmeric (Curcuma longa L.)‎, and Ginger (Zingiber officinale R.)‎ Essential Oils in Cervical Cancer Cells (HeLa)‎

المؤلفون المشاركون

Machinski Junior, Miguel
Santos, P. A. S. R.
Avanço, G. B.
Nerilo, S. B.
Marcelino, R. I. A.
Janeiro, V.
Valadares, M. C.

المصدر

The Scientific World Journal

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-11-30

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب

الملخص EN

The objective of this study was to evaluate the cytotoxic activity of rosemary (REO, Rosmarinus officinalis L.), turmeric (CEO, Curcuma longa L.), and ginger (GEO, Zingiber officinale R.) essential oils in HeLa cells.

Cytotoxicity tests were performed in vitro, using tetrazolium (MTT) and neutral red assays for evaluation of antiproliferative activity by different mechanisms, trypan blue assay to assess cell viability and evaluation of cell morphology for Giemsa to observe the cell damage, and Annexin V to evaluate cell death by apoptosis.

CEO and GEO exhibited potent cytotoxic activity against HeLa cells.

IC50 obtained was 36.6 μg/mL for CEO and 129.9 μg/mL for GEO.

The morphology of HeLa cells showed condensation of chromatin, loss of cell membrane integrity with protrusions (blebs), and cell content leakage for cells treated with CEO and GEO, from the lowest concentrations studied, 32.81 μg/mL of CEO and 32.12 μg/mL of GEO.

The Annexin V assay revealed a profile of cell death by apoptosis for both CEO and GEO.

The results indicate cytotoxic activity in vitro for CEO and GEO, suggesting potential use as anticancer agents for cervical cancer cells.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Santos, P. A. S. R.& Avanço, G. B.& Nerilo, S. B.& Marcelino, R. I. A.& Janeiro, V.& Valadares, M. C.…[et al.]. 2016. Assessment of Cytotoxic Activity of Rosemary (Rosmarinus officinalis L.), Turmeric (Curcuma longa L.), and Ginger (Zingiber officinale R.) Essential Oils in Cervical Cancer Cells (HeLa). The Scientific World Journal،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1120641

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Santos, P. A. S. R.…[et al.]. Assessment of Cytotoxic Activity of Rosemary (Rosmarinus officinalis L.), Turmeric (Curcuma longa L.), and Ginger (Zingiber officinale R.) Essential Oils in Cervical Cancer Cells (HeLa). The Scientific World Journal No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1120641

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Santos, P. A. S. R.& Avanço, G. B.& Nerilo, S. B.& Marcelino, R. I. A.& Janeiro, V.& Valadares, M. C.…[et al.]. Assessment of Cytotoxic Activity of Rosemary (Rosmarinus officinalis L.), Turmeric (Curcuma longa L.), and Ginger (Zingiber officinale R.) Essential Oils in Cervical Cancer Cells (HeLa). The Scientific World Journal. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1120641

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1120641