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Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities
المؤلفون المشاركون
Hussain, Ghulam
Rasul, Azhar
Selamoglu, Zeliha
Jabeen, Farhat
Riaz, Ammara
Zahoor, Muhammad Kashif
Subhani, Zinayyera
Younis, Tahira
Ali, Muhammad
Sarfraz, Iqra
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-02
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Natural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs.
This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as Cuscuta chinensis.
This multifaceted compound is well known for its diversified pharmacological applications such as anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties.
It carries out the aforementioned activities by the regulation and modulation of various molecular targets such as transcription factors (NF-κB, TNF-α, and TGF-β1), enzymes (iNOS, COX-2, PGE2, MMP-1, MMP-3, MIP-1α, COX-2, PGE-2, HK2, AChe, SOD, DRP-1, DDH, PLCγ1, and GPX), kinases (JNK, MAPK, Akt, ERK, SAPK, IκBα, PI3K, and PKCβ2), cell adhesion proteins (E-cadherin, vimentin PAR-2, and NCam), apoptotic and antiapoptotic proteins (Beclin-1, Bcl-2, Bax, Bcl-xL, cytochrome c, LC3A/B, caspase-3, caspase-9, procaspase-3, procaspase-8, and IgE), and inflammatory cytokines (SOCS-3, SOCS-5, IL-1β, IL-4, IL-6, IL-8, IL-13, MCP-1, CXCL-1, CXCL-2, and IFN-γ).
Although researchers have reported multiple pharmacological applications of astragalin in various diseased conditions, further experimental investigations are still mandatory to fully understand its mechanism of action.
It is contemplated that astragalin could be subjected to structural optimization to ameliorate its chemical accessibility, to optimize its absorption profiles, and to synthesize its more effective analogues which will ultimately lead towards potent drug candidates.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Riaz, Ammara& Rasul, Azhar& Hussain, Ghulam& Zahoor, Muhammad Kashif& Jabeen, Farhat& Subhani, Zinayyera…[et al.]. 2018. Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1122809
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Riaz, Ammara…[et al.]. Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities. Advances in Pharmacological and Pharmaceutical Sciences No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1122809
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Riaz, Ammara& Rasul, Azhar& Hussain, Ghulam& Zahoor, Muhammad Kashif& Jabeen, Farhat& Subhani, Zinayyera…[et al.]. Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities. Advances in Pharmacological and Pharmaceutical Sciences. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1122809
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1122809
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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