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Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities
Joint Authors
Hussain, Ghulam
Rasul, Azhar
Selamoglu, Zeliha
Jabeen, Farhat
Riaz, Ammara
Zahoor, Muhammad Kashif
Subhani, Zinayyera
Younis, Tahira
Ali, Muhammad
Sarfraz, Iqra
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-02
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Natural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs.
This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as Cuscuta chinensis.
This multifaceted compound is well known for its diversified pharmacological applications such as anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties.
It carries out the aforementioned activities by the regulation and modulation of various molecular targets such as transcription factors (NF-κB, TNF-α, and TGF-β1), enzymes (iNOS, COX-2, PGE2, MMP-1, MMP-3, MIP-1α, COX-2, PGE-2, HK2, AChe, SOD, DRP-1, DDH, PLCγ1, and GPX), kinases (JNK, MAPK, Akt, ERK, SAPK, IκBα, PI3K, and PKCβ2), cell adhesion proteins (E-cadherin, vimentin PAR-2, and NCam), apoptotic and antiapoptotic proteins (Beclin-1, Bcl-2, Bax, Bcl-xL, cytochrome c, LC3A/B, caspase-3, caspase-9, procaspase-3, procaspase-8, and IgE), and inflammatory cytokines (SOCS-3, SOCS-5, IL-1β, IL-4, IL-6, IL-8, IL-13, MCP-1, CXCL-1, CXCL-2, and IFN-γ).
Although researchers have reported multiple pharmacological applications of astragalin in various diseased conditions, further experimental investigations are still mandatory to fully understand its mechanism of action.
It is contemplated that astragalin could be subjected to structural optimization to ameliorate its chemical accessibility, to optimize its absorption profiles, and to synthesize its more effective analogues which will ultimately lead towards potent drug candidates.
American Psychological Association (APA)
Riaz, Ammara& Rasul, Azhar& Hussain, Ghulam& Zahoor, Muhammad Kashif& Jabeen, Farhat& Subhani, Zinayyera…[et al.]. 2018. Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1122809
Modern Language Association (MLA)
Riaz, Ammara…[et al.]. Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities. Advances in Pharmacological and Pharmaceutical Sciences No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1122809
American Medical Association (AMA)
Riaz, Ammara& Rasul, Azhar& Hussain, Ghulam& Zahoor, Muhammad Kashif& Jabeen, Farhat& Subhani, Zinayyera…[et al.]. Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities. Advances in Pharmacological and Pharmaceutical Sciences. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1122809
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1122809