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Neurotoxicity of Inhalation Anesthetics in the Neonatal Rat Brain: Effects on Behavior and Neurodegeneration in the Piriform Cortex
المؤلفون المشاركون
O’Farrell, Rachel A.
Foley, Andrew G.
Buggy, Donal J.
Gallagher, Helen C.
المصدر
Anesthesiology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
There is concern that clinical use of anesthetic drugs may cause neurotoxicity in the developing brain and subsequent abnormal neurobehavior.
We therefore evaluated neurotoxic effects of inhalation anesthetics in the neonatal rat brain, using in vivo histological and neurobehavioral outcomes.
Wistar rats (n=79, postnatal day 15) were subjected to a clinically relevant single exposure of urethane, isoflurane, sevoflurane, or placebo, without surgery.
At 48 h and 96 h, behavioral parameters were recorded and the animals were sacrificed.
In cryosectioned brains, total cells and dying cells in layer II of the piriform cortex were counted using unbiased stereology.
At 48 h, cell numbers in layer II of the piriform cortex of all drug-treated animals were reduced versus controls (p=0.01).
The effect persisted at 96 h in isoflurane- and urethane-exposed animals.
Piriform cortical layer II neurons undergoing degeneration, detected histologically by pyknotic nuclei and eosinophilic cytoplasm, were increased in the animals treated with isoflurane (1.9 ± 0.7 at 96 h) and urethane (2.4 ± 0.8 at 96 h) versus sevoflurane (0.8 ± 0.3 at 96 h) and controls (0.9 ± 0.2 at 96 h).
Sevoflurane- and isoflurane-treated animals exhibited increased activity and decreased suckling compared with controls, and sevoflurane-exposed animals also displayed increased rearing behavior at both timepoints.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
O’Farrell, Rachel A.& Foley, Andrew G.& Buggy, Donal J.& Gallagher, Helen C.. 2018. Neurotoxicity of Inhalation Anesthetics in the Neonatal Rat Brain: Effects on Behavior and Neurodegeneration in the Piriform Cortex. Anesthesiology Research and Practice،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1122895
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
O’Farrell, Rachel A.…[et al.]. Neurotoxicity of Inhalation Anesthetics in the Neonatal Rat Brain: Effects on Behavior and Neurodegeneration in the Piriform Cortex. Anesthesiology Research and Practice No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1122895
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
O’Farrell, Rachel A.& Foley, Andrew G.& Buggy, Donal J.& Gallagher, Helen C.. Neurotoxicity of Inhalation Anesthetics in the Neonatal Rat Brain: Effects on Behavior and Neurodegeneration in the Piriform Cortex. Anesthesiology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1122895
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1122895
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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