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Neurotoxicity of Inhalation Anesthetics in the Neonatal Rat Brain: Effects on Behavior and Neurodegeneration in the Piriform Cortex
Joint Authors
O’Farrell, Rachel A.
Foley, Andrew G.
Buggy, Donal J.
Gallagher, Helen C.
Source
Anesthesiology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
There is concern that clinical use of anesthetic drugs may cause neurotoxicity in the developing brain and subsequent abnormal neurobehavior.
We therefore evaluated neurotoxic effects of inhalation anesthetics in the neonatal rat brain, using in vivo histological and neurobehavioral outcomes.
Wistar rats (n=79, postnatal day 15) were subjected to a clinically relevant single exposure of urethane, isoflurane, sevoflurane, or placebo, without surgery.
At 48 h and 96 h, behavioral parameters were recorded and the animals were sacrificed.
In cryosectioned brains, total cells and dying cells in layer II of the piriform cortex were counted using unbiased stereology.
At 48 h, cell numbers in layer II of the piriform cortex of all drug-treated animals were reduced versus controls (p=0.01).
The effect persisted at 96 h in isoflurane- and urethane-exposed animals.
Piriform cortical layer II neurons undergoing degeneration, detected histologically by pyknotic nuclei and eosinophilic cytoplasm, were increased in the animals treated with isoflurane (1.9 ± 0.7 at 96 h) and urethane (2.4 ± 0.8 at 96 h) versus sevoflurane (0.8 ± 0.3 at 96 h) and controls (0.9 ± 0.2 at 96 h).
Sevoflurane- and isoflurane-treated animals exhibited increased activity and decreased suckling compared with controls, and sevoflurane-exposed animals also displayed increased rearing behavior at both timepoints.
American Psychological Association (APA)
O’Farrell, Rachel A.& Foley, Andrew G.& Buggy, Donal J.& Gallagher, Helen C.. 2018. Neurotoxicity of Inhalation Anesthetics in the Neonatal Rat Brain: Effects on Behavior and Neurodegeneration in the Piriform Cortex. Anesthesiology Research and Practice،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1122895
Modern Language Association (MLA)
O’Farrell, Rachel A.…[et al.]. Neurotoxicity of Inhalation Anesthetics in the Neonatal Rat Brain: Effects on Behavior and Neurodegeneration in the Piriform Cortex. Anesthesiology Research and Practice No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1122895
American Medical Association (AMA)
O’Farrell, Rachel A.& Foley, Andrew G.& Buggy, Donal J.& Gallagher, Helen C.. Neurotoxicity of Inhalation Anesthetics in the Neonatal Rat Brain: Effects on Behavior and Neurodegeneration in the Piriform Cortex. Anesthesiology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1122895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1122895