Synthesis of Pyrazolone Derivatives and Their Nanometer Ag(I) Complexes and Physicochemical, DNA Binding, Antitumor, and Theoretical Implementations
المؤلفون المشاركون
Althagafi, Ismail
El-Metwaly, Nashwa M.
Elghalban, Marwa G.
Farghaly, Thoraya A.
Khedr, Abdalla M.
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-14
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Four pyrazolone derivatives and their corresponding silver complexes were synthesized and characterized.
Based on elemental analysis, 1 : 2 (M : L) molar ratio was suggested for all inspected complexes.
1H, 13C NMR, mass, UV-Vis, TGA, and IR were the spectral tools used for describing the formulae.
Moreover, XRD patterns and SEM pictures were used to evaluate the particle sizes which appeared strongly in nanometer range.
CT-DNA study is the major consideration in this study, to test the interacting ability of all synthesized cationic complexes towards cell DNA.
Each binding constant was computed and correlated with the Hammett sigma constant.
Antitumor activity was examined upon three carcinoma cell lines (MCF-7, HepG2, and HCT116).
The high efficiency was recorded towards MCF-7 (breast carcinoma) cell line.
Kinetic studies yield essential parameters to assert on the rule of metal atom on thermal feature of organic compounds.
Molecular modeling was implemented to optimize the structures of compounds.
Also, molecular docking was achieved to obtain a clear view about proposed drug behavior within the affected cells.
This was achieved through comparing the calculated internal energy values of all docking complexes.
All the tested compounds displayed a significant interaction with breast cancer protein (strong matching with practical result) followed by DNA polymerase protein.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Althagafi, Ismail& El-Metwaly, Nashwa M.& Elghalban, Marwa G.& Farghaly, Thoraya A.& Khedr, Abdalla M.. 2018. Synthesis of Pyrazolone Derivatives and Their Nanometer Ag(I) Complexes and Physicochemical, DNA Binding, Antitumor, and Theoretical Implementations. Bioinorganic Chemistry and Applications،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1123112
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Althagafi, Ismail…[et al.]. Synthesis of Pyrazolone Derivatives and Their Nanometer Ag(I) Complexes and Physicochemical, DNA Binding, Antitumor, and Theoretical Implementations. Bioinorganic Chemistry and Applications No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1123112
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Althagafi, Ismail& El-Metwaly, Nashwa M.& Elghalban, Marwa G.& Farghaly, Thoraya A.& Khedr, Abdalla M.. Synthesis of Pyrazolone Derivatives and Their Nanometer Ag(I) Complexes and Physicochemical, DNA Binding, Antitumor, and Theoretical Implementations. Bioinorganic Chemistry and Applications. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1123112
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123112
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر