Synthesis of Pyrazolone Derivatives and Their Nanometer Ag(I) Complexes and Physicochemical, DNA Binding, Antitumor, and Theoretical Implementations
Joint Authors
Althagafi, Ismail
El-Metwaly, Nashwa M.
Elghalban, Marwa G.
Farghaly, Thoraya A.
Khedr, Abdalla M.
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Four pyrazolone derivatives and their corresponding silver complexes were synthesized and characterized.
Based on elemental analysis, 1 : 2 (M : L) molar ratio was suggested for all inspected complexes.
1H, 13C NMR, mass, UV-Vis, TGA, and IR were the spectral tools used for describing the formulae.
Moreover, XRD patterns and SEM pictures were used to evaluate the particle sizes which appeared strongly in nanometer range.
CT-DNA study is the major consideration in this study, to test the interacting ability of all synthesized cationic complexes towards cell DNA.
Each binding constant was computed and correlated with the Hammett sigma constant.
Antitumor activity was examined upon three carcinoma cell lines (MCF-7, HepG2, and HCT116).
The high efficiency was recorded towards MCF-7 (breast carcinoma) cell line.
Kinetic studies yield essential parameters to assert on the rule of metal atom on thermal feature of organic compounds.
Molecular modeling was implemented to optimize the structures of compounds.
Also, molecular docking was achieved to obtain a clear view about proposed drug behavior within the affected cells.
This was achieved through comparing the calculated internal energy values of all docking complexes.
All the tested compounds displayed a significant interaction with breast cancer protein (strong matching with practical result) followed by DNA polymerase protein.
American Psychological Association (APA)
Althagafi, Ismail& El-Metwaly, Nashwa M.& Elghalban, Marwa G.& Farghaly, Thoraya A.& Khedr, Abdalla M.. 2018. Synthesis of Pyrazolone Derivatives and Their Nanometer Ag(I) Complexes and Physicochemical, DNA Binding, Antitumor, and Theoretical Implementations. Bioinorganic Chemistry and Applications،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1123112
Modern Language Association (MLA)
Althagafi, Ismail…[et al.]. Synthesis of Pyrazolone Derivatives and Their Nanometer Ag(I) Complexes and Physicochemical, DNA Binding, Antitumor, and Theoretical Implementations. Bioinorganic Chemistry and Applications No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1123112
American Medical Association (AMA)
Althagafi, Ismail& El-Metwaly, Nashwa M.& Elghalban, Marwa G.& Farghaly, Thoraya A.& Khedr, Abdalla M.. Synthesis of Pyrazolone Derivatives and Their Nanometer Ag(I) Complexes and Physicochemical, DNA Binding, Antitumor, and Theoretical Implementations. Bioinorganic Chemistry and Applications. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1123112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123112