Synthesis, Structure, DNA Interaction, and SOD Activity of Three Nickel(II) Complexes Containing L-Phenylalanine Schiff Base and 1,10-Phenanthroline
المؤلفون المشاركون
Li, Lianzhi
Zhao, Peiran
Zhai, Shanshan
Dong, Jianfang
Gao, Lei
Liu, Xinru
Wang, Lei
Kong, Jinming
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-05
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Three hexacoordinated octahedral nickel(II) complexes, [Ni(sal-L-phe)(phen)(CH3OH)]⋅CH3OH (1), [Ni(naph-L-phe)(phen)(CH3OH)] (2), and [Ni(o-van-L-phe)(phen)(CH3OH)]⋅5CH3OH (3) (sal-L-phe = a Schiff base derived from salicylaldehyde and L-phenylalanine, naph-L-phe = a Schiff base derived from 2-hydroxy-1-naphthaldehyde and L-phenylalanine, o-van-L-phe = a Schiff base derived from o-vanillin and L-phenylalanine, and phen = 1,10-phenanthroline), have been synthesized and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction.
The interactions of these complexes with CT-DNA were studied by UV-Vis absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy, and viscosity measurements.
The binding constant (Kb) values of 1.82 × 104 M−1 for 1, 1.96 × 104 M−1 for 2, and 2.02 × 104 M−1 for 3 suggest that each of these complexes could bind with DNA in a moderate intercalative mode.
Complex 3 exhibited a stronger interaction with CT-DNA than complexes 1 and 2.
In addition, the superoxide scavenging activity of these complexes was investigated by the nitrotetrazolium blue chloride (NBT) light reduction method, and the results showed that they exhibited a significant superoxide scavenging activity with the IC50 values of 4.4 × 10−5 M for complex 1, 5.6 × 10−5 M for complex 2, and 3.1 × 10−5 M for complex 3, respectively.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Peiran& Zhai, Shanshan& Dong, Jianfang& Gao, Lei& Liu, Xinru& Wang, Lei…[et al.]. 2018. Synthesis, Structure, DNA Interaction, and SOD Activity of Three Nickel(II) Complexes Containing L-Phenylalanine Schiff Base and 1,10-Phenanthroline. Bioinorganic Chemistry and Applications،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1123221
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Peiran…[et al.]. Synthesis, Structure, DNA Interaction, and SOD Activity of Three Nickel(II) Complexes Containing L-Phenylalanine Schiff Base and 1,10-Phenanthroline. Bioinorganic Chemistry and Applications No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1123221
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Peiran& Zhai, Shanshan& Dong, Jianfang& Gao, Lei& Liu, Xinru& Wang, Lei…[et al.]. Synthesis, Structure, DNA Interaction, and SOD Activity of Three Nickel(II) Complexes Containing L-Phenylalanine Schiff Base and 1,10-Phenanthroline. Bioinorganic Chemistry and Applications. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1123221
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123221
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر