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Synthesis, Structure, DNA Interaction, and SOD Activity of Three Nickel(II) Complexes Containing L-Phenylalanine Schiff Base and 1,10-Phenanthroline
Joint Authors
Li, Lianzhi
Zhao, Peiran
Zhai, Shanshan
Dong, Jianfang
Gao, Lei
Liu, Xinru
Wang, Lei
Kong, Jinming
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-05
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Three hexacoordinated octahedral nickel(II) complexes, [Ni(sal-L-phe)(phen)(CH3OH)]⋅CH3OH (1), [Ni(naph-L-phe)(phen)(CH3OH)] (2), and [Ni(o-van-L-phe)(phen)(CH3OH)]⋅5CH3OH (3) (sal-L-phe = a Schiff base derived from salicylaldehyde and L-phenylalanine, naph-L-phe = a Schiff base derived from 2-hydroxy-1-naphthaldehyde and L-phenylalanine, o-van-L-phe = a Schiff base derived from o-vanillin and L-phenylalanine, and phen = 1,10-phenanthroline), have been synthesized and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction.
The interactions of these complexes with CT-DNA were studied by UV-Vis absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy, and viscosity measurements.
The binding constant (Kb) values of 1.82 × 104 M−1 for 1, 1.96 × 104 M−1 for 2, and 2.02 × 104 M−1 for 3 suggest that each of these complexes could bind with DNA in a moderate intercalative mode.
Complex 3 exhibited a stronger interaction with CT-DNA than complexes 1 and 2.
In addition, the superoxide scavenging activity of these complexes was investigated by the nitrotetrazolium blue chloride (NBT) light reduction method, and the results showed that they exhibited a significant superoxide scavenging activity with the IC50 values of 4.4 × 10−5 M for complex 1, 5.6 × 10−5 M for complex 2, and 3.1 × 10−5 M for complex 3, respectively.
American Psychological Association (APA)
Zhao, Peiran& Zhai, Shanshan& Dong, Jianfang& Gao, Lei& Liu, Xinru& Wang, Lei…[et al.]. 2018. Synthesis, Structure, DNA Interaction, and SOD Activity of Three Nickel(II) Complexes Containing L-Phenylalanine Schiff Base and 1,10-Phenanthroline. Bioinorganic Chemistry and Applications،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1123221
Modern Language Association (MLA)
Zhao, Peiran…[et al.]. Synthesis, Structure, DNA Interaction, and SOD Activity of Three Nickel(II) Complexes Containing L-Phenylalanine Schiff Base and 1,10-Phenanthroline. Bioinorganic Chemistry and Applications No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1123221
American Medical Association (AMA)
Zhao, Peiran& Zhai, Shanshan& Dong, Jianfang& Gao, Lei& Liu, Xinru& Wang, Lei…[et al.]. Synthesis, Structure, DNA Interaction, and SOD Activity of Three Nickel(II) Complexes Containing L-Phenylalanine Schiff Base and 1,10-Phenanthroline. Bioinorganic Chemistry and Applications. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1123221
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123221