The Role of Immune Regulatory Cells in Nontraumatic Osteonecrosis of the Femoral Head: A Retrospective Clinical Study
المؤلفون المشاركون
Gao, Fuqiang
Sun, Wei
Wang, Weiguo
Wang, Bailiang
Ma, Jinhui
Ge, Juncheng
Yue, Debo
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The immunologic factors have been implicated in the pathogenesis of osteonecrosis.
We aimed to investigate the potential role of immune regulatory cells in the development of osteonecrosis of femoral head (ONFH).
Sixty-seven patients diagnosed with ONFH and fifty-eight age-, height-, and weight-matched healthy subjects were included in this retrospective study between September 2015 and September 2018.
The flow cytometry was used to test the count, percentage, and ratio of T and B lymphocyte subsets in peripheral blood.
The T and B lymphocyte levels were compared among different ARCO stages, CJFH types, and etiology groups.
The total lymphocyte count, CD3+T cells, Ts cells (CD3+CD8+), B-1 cell count, and B-1 cells (CD5+CD19+) were significantly higher in the patients with ONFH than those in the control subjects.
The percentage of T lymphocytes in the patients with ARCO IV stage was significantly smaller than that in the ONFH patients with ARCO II and III stages.
The percentage of inhibitory T lymphocytes in patients with CJFH type L3 was significantly smaller than that in the patients with types L1 and L2.
In terms of the different ONFH etiologies, the total lymphocyte count and Ts cells (CD3+CD8+) were significantly lower in the ONFH patients induced by excessive alcohol intake than those in the idiopathic ONFH patients.
Our results seem to indicate that immune regulatory cells, such as T and B lymphocytes, play an important role in the pathogenesis of ONFH.
The development and progression of ONFH may be associated with immune system imbalance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Jinhui& Ge, Juncheng& Gao, Fuqiang& Wang, Bailiang& Yue, Debo& Sun, Wei…[et al.]. 2019. The Role of Immune Regulatory Cells in Nontraumatic Osteonecrosis of the Femoral Head: A Retrospective Clinical Study. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1123262
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Jinhui…[et al.]. The Role of Immune Regulatory Cells in Nontraumatic Osteonecrosis of the Femoral Head: A Retrospective Clinical Study. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1123262
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Jinhui& Ge, Juncheng& Gao, Fuqiang& Wang, Bailiang& Yue, Debo& Sun, Wei…[et al.]. The Role of Immune Regulatory Cells in Nontraumatic Osteonecrosis of the Femoral Head: A Retrospective Clinical Study. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1123262
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123262
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر