The Role of Immune Regulatory Cells in Nontraumatic Osteonecrosis of the Femoral Head: A Retrospective Clinical Study
Joint Authors
Gao, Fuqiang
Sun, Wei
Wang, Weiguo
Wang, Bailiang
Ma, Jinhui
Ge, Juncheng
Yue, Debo
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The immunologic factors have been implicated in the pathogenesis of osteonecrosis.
We aimed to investigate the potential role of immune regulatory cells in the development of osteonecrosis of femoral head (ONFH).
Sixty-seven patients diagnosed with ONFH and fifty-eight age-, height-, and weight-matched healthy subjects were included in this retrospective study between September 2015 and September 2018.
The flow cytometry was used to test the count, percentage, and ratio of T and B lymphocyte subsets in peripheral blood.
The T and B lymphocyte levels were compared among different ARCO stages, CJFH types, and etiology groups.
The total lymphocyte count, CD3+T cells, Ts cells (CD3+CD8+), B-1 cell count, and B-1 cells (CD5+CD19+) were significantly higher in the patients with ONFH than those in the control subjects.
The percentage of T lymphocytes in the patients with ARCO IV stage was significantly smaller than that in the ONFH patients with ARCO II and III stages.
The percentage of inhibitory T lymphocytes in patients with CJFH type L3 was significantly smaller than that in the patients with types L1 and L2.
In terms of the different ONFH etiologies, the total lymphocyte count and Ts cells (CD3+CD8+) were significantly lower in the ONFH patients induced by excessive alcohol intake than those in the idiopathic ONFH patients.
Our results seem to indicate that immune regulatory cells, such as T and B lymphocytes, play an important role in the pathogenesis of ONFH.
The development and progression of ONFH may be associated with immune system imbalance.
American Psychological Association (APA)
Ma, Jinhui& Ge, Juncheng& Gao, Fuqiang& Wang, Bailiang& Yue, Debo& Sun, Wei…[et al.]. 2019. The Role of Immune Regulatory Cells in Nontraumatic Osteonecrosis of the Femoral Head: A Retrospective Clinical Study. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1123262
Modern Language Association (MLA)
Ma, Jinhui…[et al.]. The Role of Immune Regulatory Cells in Nontraumatic Osteonecrosis of the Femoral Head: A Retrospective Clinical Study. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1123262
American Medical Association (AMA)
Ma, Jinhui& Ge, Juncheng& Gao, Fuqiang& Wang, Bailiang& Yue, Debo& Sun, Wei…[et al.]. The Role of Immune Regulatory Cells in Nontraumatic Osteonecrosis of the Femoral Head: A Retrospective Clinical Study. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1123262
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123262