A Glance at the Nuclear Envelope Spectrin Repeat Protein 3

المؤلفون المشاركون

Rongmei, Qu
Jingxing, Dai
Liao, Liwei
Ouang, Jun

المصدر

BioMed Research International

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-11-20

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Nuclear envelope spectrin repeat protein 3 (nesprin-3) is an evolutionarily-conserved structural protein, widely-expressed in vertebrate cells.

Along with other nesprin family members, nesprin-3 acts as an essential component of the linker of nucleoskeleton and cytoskeleton (LINC) complex.

Naturally, nesprin-3 shares many functions with LINC, including the localization of various cellular structures and bridging of the nucleoskeleton and cytoskeleton, observed in vitro.

When nesprin-3 was knocked down in vivo, using zebrafish and mouse models, however, the animals were minimally affected.

This paradoxical observation should not limit the physiological importance of nesprin-3, as recently, nesprin-3 has reignited the interest of the research community in studies on cancer cells migration.

Moreover, nesprin-3 also plays an active role in certain developmental conditions such as adipogenesis and spermatogenesis, although more studies are needed.

Meanwhile, the various protein binding partners of nesprin-3 should also be emphasized, as they are necessary for maintaining the structure of nesprin-3 and enabling it to carry out its various physiological and pathological functions.

Nesprin-3 promises to further our understanding of these complex cellular events.

Therefore, this review will focus on nesprin-3, examining it from a genetic, structural, and functional perspective.

The final part of the review will in turn address the limitations of existing research and the future perspectives for the study of nesprin-3.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Liao, Liwei& Rongmei, Qu& Ouang, Jun& Jingxing, Dai. 2019. A Glance at the Nuclear Envelope Spectrin Repeat Protein 3. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123452

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Liao, Liwei…[et al.]. A Glance at the Nuclear Envelope Spectrin Repeat Protein 3. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1123452

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Liao, Liwei& Rongmei, Qu& Ouang, Jun& Jingxing, Dai. A Glance at the Nuclear Envelope Spectrin Repeat Protein 3. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123452

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1123452