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A Glance at the Nuclear Envelope Spectrin Repeat Protein 3
Joint Authors
Rongmei, Qu
Jingxing, Dai
Liao, Liwei
Ouang, Jun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nuclear envelope spectrin repeat protein 3 (nesprin-3) is an evolutionarily-conserved structural protein, widely-expressed in vertebrate cells.
Along with other nesprin family members, nesprin-3 acts as an essential component of the linker of nucleoskeleton and cytoskeleton (LINC) complex.
Naturally, nesprin-3 shares many functions with LINC, including the localization of various cellular structures and bridging of the nucleoskeleton and cytoskeleton, observed in vitro.
When nesprin-3 was knocked down in vivo, using zebrafish and mouse models, however, the animals were minimally affected.
This paradoxical observation should not limit the physiological importance of nesprin-3, as recently, nesprin-3 has reignited the interest of the research community in studies on cancer cells migration.
Moreover, nesprin-3 also plays an active role in certain developmental conditions such as adipogenesis and spermatogenesis, although more studies are needed.
Meanwhile, the various protein binding partners of nesprin-3 should also be emphasized, as they are necessary for maintaining the structure of nesprin-3 and enabling it to carry out its various physiological and pathological functions.
Nesprin-3 promises to further our understanding of these complex cellular events.
Therefore, this review will focus on nesprin-3, examining it from a genetic, structural, and functional perspective.
The final part of the review will in turn address the limitations of existing research and the future perspectives for the study of nesprin-3.
American Psychological Association (APA)
Liao, Liwei& Rongmei, Qu& Ouang, Jun& Jingxing, Dai. 2019. A Glance at the Nuclear Envelope Spectrin Repeat Protein 3. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123452
Modern Language Association (MLA)
Liao, Liwei…[et al.]. A Glance at the Nuclear Envelope Spectrin Repeat Protein 3. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1123452
American Medical Association (AMA)
Liao, Liwei& Rongmei, Qu& Ouang, Jun& Jingxing, Dai. A Glance at the Nuclear Envelope Spectrin Repeat Protein 3. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1123452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123452