Expression Profiling of Exosomal miRNAs Derived from the Peripheral Blood of Kidney Recipients with DGF Using High-Throughput Sequencing
المؤلفون المشاركون
Wang, Junpeng
Li, Xin
Wu, Xiaoqiang
Wang, Zhiwei
Zhang, Chan
Cao, Guanghui
Yan, Tianzhong
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-12
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Delayed graft function (DGF) is one of the major obstacles for graft survival for kidney recipients.
It is profound to reduce the incidence of DGF for maintaining long-term graft survival.
However, the molecular regulation of DGF is still not adequately explained and the biomarkers for DGF are limited.
Exosomes are cell-derived membrane vesicles, contents of which are stable and could be delivered into recipient cells to exert their biological functions.
Consequently, exosome-derived proteomic and RNA signature profiles are often used to account for the molecular regulation of diseases or reflect the conditional state of their tissue as biomarkers.
Few researches have been done to demonstrate the function of exosomes associated with DGF.
In this study, high-throughput sequencing was used to explore the miRNA expression profiling of exosomes in the peripheral blood of kidney recipients with DGF.
We identified 52 known and 5 conserved exosomal miRNAs specifically expressed in recipients with DGF.
Three coexpressed miRNAs, hsa-miR-33a-5p_R-1, hsa-miR-98-5p, and hsa-miR-151a-5p, were observed to be significantly upregulated in kidney recipients with DGF.
Moreover, hsa-miR-151a-5p was positively correlated with the first-week serum CR, BUN, and UA levels of the kidney recipients after transplantation.
Furthermore, we also analyzed functions and signaling pathways of the three upregulated miRNAs target genes to uncover putative mechanism of how these exosomal miRNAs functioned in DGF.
Overall, these findings identified biomarker candidates for DGF and provided new insights into the important role of the exosomal miRNAs regulation in DGF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Junpeng& Li, Xin& Wu, Xiaoqiang& Wang, Zhiwei& Zhang, Chan& Cao, Guanghui…[et al.]. 2019. Expression Profiling of Exosomal miRNAs Derived from the Peripheral Blood of Kidney Recipients with DGF Using High-Throughput Sequencing. BioMed Research International،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1123495
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Junpeng…[et al.]. Expression Profiling of Exosomal miRNAs Derived from the Peripheral Blood of Kidney Recipients with DGF Using High-Throughput Sequencing. BioMed Research International No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1123495
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Junpeng& Li, Xin& Wu, Xiaoqiang& Wang, Zhiwei& Zhang, Chan& Cao, Guanghui…[et al.]. Expression Profiling of Exosomal miRNAs Derived from the Peripheral Blood of Kidney Recipients with DGF Using High-Throughput Sequencing. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1123495
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123495
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر