Vasculogenic Mimicry Formation Is Associated with Erythropoietin Expression but Not with Erythropoietin Receptor Expression in Cervical Squamous Cell Carcinoma
المؤلفون المشاركون
Li, Yue-Jie
Qing, Xin
Tao, Qing-Xu
Xiang, Li
Gong, Li
Zhou, Tie-Jun
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Vasculogenic mimicry (VM), as an endothelium-independent cancer microcirculation, has been observed in many malignancies including cervical cancer.
Erythropoietin (EPO) and erythropoietin receptor (EPO-R) could produce an angiogenic effect to promote cervical squamous cell carcinoma (CSCC) progression.
However, the association between VM formation and EPO/EPO-R expression in CSCC is poorly explored.
Methods.
Seventy-six paraffin-embedded CSCC samples, 25 high-grade squamous intraepithelial lesion (HSIL) samples, 20 low-grade squamous intraepithelial lesion (LSIL) samples, and 20 normal cervix samples were collected.
Immunohistochemistry SP method was performed to detect EPO/EPO-R expression and CD31/periodic acid-Schiff (PAS) double staining was performed to detect VM formation.
The associations of EPO/EPO-R and VM with clinicopathological parameters of CSCC were analyzed.
The associations between VM formation and EPO/EPO-R expression were also analyzed.
Results.
The positive expression rates of EPO and EPO-R were gradually increasing along the progression of normal cervix-LSIL-HSIL-CSCC sequence (P<0.05).
EPO and EPO-R expression were not significantly associated with clinicopathological parameters of CSCC patients (P>0.05).
VM was significantly associated with FIGO stage, lymphovascular space involvement, and lymph node metastasis (P<0.05).
VM was positively associated with EPO expression (r=0.284, P<0.05) but was not associated with EPO-R expression (P>0.05).
Conclusion.
These data suggest that increased EPO/EPO-R expression may play an important role in cervical carcinogenesis.
EPO overexpression may promote VM formation in CSCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yue-Jie& Qing, Xin& Tao, Qing-Xu& Xiang, Li& Gong, Li& Zhou, Tie-Jun. 2019. Vasculogenic Mimicry Formation Is Associated with Erythropoietin Expression but Not with Erythropoietin Receptor Expression in Cervical Squamous Cell Carcinoma. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123574
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yue-Jie…[et al.]. Vasculogenic Mimicry Formation Is Associated with Erythropoietin Expression but Not with Erythropoietin Receptor Expression in Cervical Squamous Cell Carcinoma. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1123574
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yue-Jie& Qing, Xin& Tao, Qing-Xu& Xiang, Li& Gong, Li& Zhou, Tie-Jun. Vasculogenic Mimicry Formation Is Associated with Erythropoietin Expression but Not with Erythropoietin Receptor Expression in Cervical Squamous Cell Carcinoma. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123574
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123574
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر