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Vasculogenic Mimicry Formation Is Associated with Erythropoietin Expression but Not with Erythropoietin Receptor Expression in Cervical Squamous Cell Carcinoma
Joint Authors
Li, Yue-Jie
Qing, Xin
Tao, Qing-Xu
Xiang, Li
Gong, Li
Zhou, Tie-Jun
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Vasculogenic mimicry (VM), as an endothelium-independent cancer microcirculation, has been observed in many malignancies including cervical cancer.
Erythropoietin (EPO) and erythropoietin receptor (EPO-R) could produce an angiogenic effect to promote cervical squamous cell carcinoma (CSCC) progression.
However, the association between VM formation and EPO/EPO-R expression in CSCC is poorly explored.
Methods.
Seventy-six paraffin-embedded CSCC samples, 25 high-grade squamous intraepithelial lesion (HSIL) samples, 20 low-grade squamous intraepithelial lesion (LSIL) samples, and 20 normal cervix samples were collected.
Immunohistochemistry SP method was performed to detect EPO/EPO-R expression and CD31/periodic acid-Schiff (PAS) double staining was performed to detect VM formation.
The associations of EPO/EPO-R and VM with clinicopathological parameters of CSCC were analyzed.
The associations between VM formation and EPO/EPO-R expression were also analyzed.
Results.
The positive expression rates of EPO and EPO-R were gradually increasing along the progression of normal cervix-LSIL-HSIL-CSCC sequence (P<0.05).
EPO and EPO-R expression were not significantly associated with clinicopathological parameters of CSCC patients (P>0.05).
VM was significantly associated with FIGO stage, lymphovascular space involvement, and lymph node metastasis (P<0.05).
VM was positively associated with EPO expression (r=0.284, P<0.05) but was not associated with EPO-R expression (P>0.05).
Conclusion.
These data suggest that increased EPO/EPO-R expression may play an important role in cervical carcinogenesis.
EPO overexpression may promote VM formation in CSCC.
American Psychological Association (APA)
Li, Yue-Jie& Qing, Xin& Tao, Qing-Xu& Xiang, Li& Gong, Li& Zhou, Tie-Jun. 2019. Vasculogenic Mimicry Formation Is Associated with Erythropoietin Expression but Not with Erythropoietin Receptor Expression in Cervical Squamous Cell Carcinoma. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123574
Modern Language Association (MLA)
Li, Yue-Jie…[et al.]. Vasculogenic Mimicry Formation Is Associated with Erythropoietin Expression but Not with Erythropoietin Receptor Expression in Cervical Squamous Cell Carcinoma. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1123574
American Medical Association (AMA)
Li, Yue-Jie& Qing, Xin& Tao, Qing-Xu& Xiang, Li& Gong, Li& Zhou, Tie-Jun. Vasculogenic Mimicry Formation Is Associated with Erythropoietin Expression but Not with Erythropoietin Receptor Expression in Cervical Squamous Cell Carcinoma. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123574