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Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum
المؤلفون المشاركون
Laghmich, Achraf
Alaoui Ismaili, Fatima Zahra
Barakat, Amina
Ghailani Nourouti, Naima
Khattab, Mohamed
Bennani Mechita, Mohcine
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Unlike the other hemoglobinopathies, few researches have been published concerning α-thalassemia in Morocco.
The epidemiological features and the mutation spectrum of this disease are still unknown.
This regional newborn screening is the first to study α-thalassemia in the north of Morocco.
During the period from January 2015 to December 2016, 1658 newborns umbilical blood samples were investigated.
Suspected newborns were screened for α-globin defects using Gap-PCR and Multiplex Ligation-dependent Probe Amplification technique.
The prevalence of α-thalassemia, its mutation spectrum, and its allelic frequencies were described for the first time in Morocco.
Six different α-globin genetic disorders were detected in 16 neonates.
This screening valued the prevalence of α-thalassemia in the studied population at 0.96% and showed the wide mutation spectrum and the heterogeneous geographical distribution of the disease.
A high rate of carriers was observed in Laouamra, a rural commune in Larache province.
Heterogeneity of α-globin alleles in Morocco explains the high variability of α-thalassemia severity.
This diversity reflects the anthropological history of the country.
These results would contribute to the prevention of thalassemia in Morocco directing the design of a nationwide screening strategy and awareness campaign.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Laghmich, Achraf& Alaoui Ismaili, Fatima Zahra& Barakat, Amina& Ghailani Nourouti, Naima& Khattab, Mohamed& Bennani Mechita, Mohcine. 2019. Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1123678
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Laghmich, Achraf…[et al.]. Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1123678
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Laghmich, Achraf& Alaoui Ismaili, Fatima Zahra& Barakat, Amina& Ghailani Nourouti, Naima& Khattab, Mohamed& Bennani Mechita, Mohcine. Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1123678
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123678
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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