Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum
Joint Authors
Laghmich, Achraf
Alaoui Ismaili, Fatima Zahra
Barakat, Amina
Ghailani Nourouti, Naima
Khattab, Mohamed
Bennani Mechita, Mohcine
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Unlike the other hemoglobinopathies, few researches have been published concerning α-thalassemia in Morocco.
The epidemiological features and the mutation spectrum of this disease are still unknown.
This regional newborn screening is the first to study α-thalassemia in the north of Morocco.
During the period from January 2015 to December 2016, 1658 newborns umbilical blood samples were investigated.
Suspected newborns were screened for α-globin defects using Gap-PCR and Multiplex Ligation-dependent Probe Amplification technique.
The prevalence of α-thalassemia, its mutation spectrum, and its allelic frequencies were described for the first time in Morocco.
Six different α-globin genetic disorders were detected in 16 neonates.
This screening valued the prevalence of α-thalassemia in the studied population at 0.96% and showed the wide mutation spectrum and the heterogeneous geographical distribution of the disease.
A high rate of carriers was observed in Laouamra, a rural commune in Larache province.
Heterogeneity of α-globin alleles in Morocco explains the high variability of α-thalassemia severity.
This diversity reflects the anthropological history of the country.
These results would contribute to the prevention of thalassemia in Morocco directing the design of a nationwide screening strategy and awareness campaign.
American Psychological Association (APA)
Laghmich, Achraf& Alaoui Ismaili, Fatima Zahra& Barakat, Amina& Ghailani Nourouti, Naima& Khattab, Mohamed& Bennani Mechita, Mohcine. 2019. Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1123678
Modern Language Association (MLA)
Laghmich, Achraf…[et al.]. Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1123678
American Medical Association (AMA)
Laghmich, Achraf& Alaoui Ismaili, Fatima Zahra& Barakat, Amina& Ghailani Nourouti, Naima& Khattab, Mohamed& Bennani Mechita, Mohcine. Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1123678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123678