Moringa peregrina Leaves Extracts Induce Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma
المؤلفون المشاركون
Mansour, Mohamed
Mohamed, Magda F.
Elhalwagi, Abeer
El-Itriby, Hanaiya A.
Shawki, Hossam H.
Abdelhamid, Ismail A.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Moringa grows in the tropical and subtropical regions of the world.
The genus Moringa belongs to family Moringaceae.
It is found to possess various medicinal uses including hypoglycemic, analgesic, anti-inflammatory, hypolipidemic, and antioxidant activities.
In this study, we investigated the antimicrobial and the anticancer activity of the Moringa peregrina as well as Moringa oleifera leaves extracts grown locally in Egypt.
Results indicated that most of the extracts were found to possess high antimicrobial activity against gram-positive bacteria, gram-negative bacteria, and fungus.
The survival rate of cancer cells was decreased in both hepatocellular carcinoma (HepG2) and breast carcinoma (MCF-7) cell lines when treated with Moringa leaves extracts.
In addition, the cell cycle progression, apoptosis, and cancer-related genes confirmed its anticancer effect.
The toxicity of each extract was also tested using the normal melanocytes cell line HFB4.
The toxicity was low in both Moringa peregrina and Moringa oleifera leaves extracts.
Furthermore, GC/MS analysis fractionized the phytochemicals content for each potential extract.
In conclusion, results suggested that the Moringa peregrina and Moringa oleifera leaves extracts possess antimicrobial and anticancer properties which could be attributed to the bioactive phytochemical compounds present inside the extracts from this plant.
These findings can be used to develop new drugs, especially for liver cancer chemotherapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mansour, Mohamed& Mohamed, Magda F.& Elhalwagi, Abeer& El-Itriby, Hanaiya A.& Shawki, Hossam H.& Abdelhamid, Ismail A.. 2019. Moringa peregrina Leaves Extracts Induce Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1124025
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mansour, Mohamed…[et al.]. Moringa peregrina Leaves Extracts Induce Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1124025
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mansour, Mohamed& Mohamed, Magda F.& Elhalwagi, Abeer& El-Itriby, Hanaiya A.& Shawki, Hossam H.& Abdelhamid, Ismail A.. Moringa peregrina Leaves Extracts Induce Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1124025
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124025
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر