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Moringa peregrina Leaves Extracts Induce Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma
Joint Authors
Mansour, Mohamed
Mohamed, Magda F.
Elhalwagi, Abeer
El-Itriby, Hanaiya A.
Shawki, Hossam H.
Abdelhamid, Ismail A.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Moringa grows in the tropical and subtropical regions of the world.
The genus Moringa belongs to family Moringaceae.
It is found to possess various medicinal uses including hypoglycemic, analgesic, anti-inflammatory, hypolipidemic, and antioxidant activities.
In this study, we investigated the antimicrobial and the anticancer activity of the Moringa peregrina as well as Moringa oleifera leaves extracts grown locally in Egypt.
Results indicated that most of the extracts were found to possess high antimicrobial activity against gram-positive bacteria, gram-negative bacteria, and fungus.
The survival rate of cancer cells was decreased in both hepatocellular carcinoma (HepG2) and breast carcinoma (MCF-7) cell lines when treated with Moringa leaves extracts.
In addition, the cell cycle progression, apoptosis, and cancer-related genes confirmed its anticancer effect.
The toxicity of each extract was also tested using the normal melanocytes cell line HFB4.
The toxicity was low in both Moringa peregrina and Moringa oleifera leaves extracts.
Furthermore, GC/MS analysis fractionized the phytochemicals content for each potential extract.
In conclusion, results suggested that the Moringa peregrina and Moringa oleifera leaves extracts possess antimicrobial and anticancer properties which could be attributed to the bioactive phytochemical compounds present inside the extracts from this plant.
These findings can be used to develop new drugs, especially for liver cancer chemotherapy.
American Psychological Association (APA)
Mansour, Mohamed& Mohamed, Magda F.& Elhalwagi, Abeer& El-Itriby, Hanaiya A.& Shawki, Hossam H.& Abdelhamid, Ismail A.. 2019. Moringa peregrina Leaves Extracts Induce Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1124025
Modern Language Association (MLA)
Mansour, Mohamed…[et al.]. Moringa peregrina Leaves Extracts Induce Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1124025
American Medical Association (AMA)
Mansour, Mohamed& Mohamed, Magda F.& Elhalwagi, Abeer& El-Itriby, Hanaiya A.& Shawki, Hossam H.& Abdelhamid, Ismail A.. Moringa peregrina Leaves Extracts Induce Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1124025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124025