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Transcriptome Sequencing to Detect the Potential Role of Long Noncoding RNAs in Salt-Sensitive Hypertensive Rats
المؤلفون المشاركون
Wu, Hao
Zhu, Sibo
Yuan, Rui
Yi, Yang
Wang, Hanqing
Gu, Bo
Zhen, Timing
Xing, Kaichen
Ma, Jun
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-06
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Backgrounds.
Long noncoding RNAs (lncRNAs) play an important role in various biological processes.
However, their functions in salt-sensitive hypertension are largely unknown.
In this study, the lncRNA-seq technique was employed to compare the expression profiles of lncRNAs and mRNAs in salt-sensitive hypertensive rats.
Methods.
Blood pressure, serum sodium, and urinary creatinine were texted in salt-sensitive and salt-insensitive rats fed with different salt concentrations.
High-throughput sequencing was used to detect the expression of lncRNAs and mRNA in the renal medulla of the two groups.
Results.
Blood pressure and urinary sodium/creatinine of high-salt diets of the sensitive group were significantly higher than that in the control group.
Serum sodium has no significant difference between the two groups in high-salt diets.
NONRATG007131.2 and NONRATG012674.2 were the most different lncRNAs in the high salt-sensitive group.
Correlation analysis reveals that Matn1, Serpinb12, Anxa8, and Hspa5 may play an important role in salt-sensitive hypertension.
Conclusion.
This study analyzed the difference in lncRNA and mRNA between salt-sensitive and salt-insensitive rats with different salt diets by high-throughput sequencing.
Salt sensitivity and salt concentration were two key factors for the induction of hypertension.
We found some potential genes that play an important role in salt-sensitive hypertension.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Hao& Zhu, Sibo& Yuan, Rui& Yi, Yang& Wang, Hanqing& Gu, Bo…[et al.]. 2019. Transcriptome Sequencing to Detect the Potential Role of Long Noncoding RNAs in Salt-Sensitive Hypertensive Rats. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124106
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Hao…[et al.]. Transcriptome Sequencing to Detect the Potential Role of Long Noncoding RNAs in Salt-Sensitive Hypertensive Rats. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1124106
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Hao& Zhu, Sibo& Yuan, Rui& Yi, Yang& Wang, Hanqing& Gu, Bo…[et al.]. Transcriptome Sequencing to Detect the Potential Role of Long Noncoding RNAs in Salt-Sensitive Hypertensive Rats. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124106
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124106
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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