Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model
المؤلفون المشاركون
Shu, Yilai
Shi, Fang
Yang, Yue
Chen, Jian
Sha, Yan
Wu, Haitao
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-17
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the potential use of indirect computed tomography lymphography (CT-LG) with dendrimer-entrapped gold nanoparticles (Au DENPs) in the localization and enhanced imaging of cervical sentinel lymph node (SLN) on rabbit model.
Methods.
Twelve rabbits were randomly divided into two groups: the positive control group and the experimental group.
In the control group, indirect CT-LG was performed with the injection of 0.5 ml activated carbon nanoparticles (ACNP) and Omnipaque mixture suspension in the right tongue submucosa.
CT images were acquired before the injection and 1, 5, 10, and 15 min after the injection, respectively.
In the experimental group, indirect CT-LG injection with 0.5 ml Au DENPs suspension was performed in the right tongue submucosa.
CT images were obtained before the injection and 1, 5, 10, and 15 min and 1, 2, 6, 24, 48, and 72 h after the injection, respectively.
Then, SLN identification and enhancement characteristics were evaluated.
Results.
Indirect CT-LG revealed the enhancement of one right deep cervical lymph nodes in all animals, which was SLN.
SLN location was marked with black color (ACNP dye) or purple-black color (Au DENPs dye).
At each detection time point, the enhanced SLN attenuation values of control rabbits were statistically significantly higher than that of the plain scan, respectively ( P < 0.05 ).
Also the values of experimental rabbits were statistically significantly higher than that of the control at the same time point after injection ( P < 0.05 ).
The detection rate of SLN was 100%.
Conclusions.
Indirect CT-LG with injection of Au DENPs as CT contrast agents can locate the SLN for a long period of time and enrich the SLN black dye.
It is helpful for SLNs identification during the operation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Fang& Yang, Yue& Chen, Jian& Sha, Yan& Shu, Yilai& Wu, Haitao. 2018. Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1124172
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Fang…[et al.]. Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1124172
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Fang& Yang, Yue& Chen, Jian& Sha, Yan& Shu, Yilai& Wu, Haitao. Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1124172
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124172
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر