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Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model
Joint Authors
Shu, Yilai
Shi, Fang
Yang, Yue
Chen, Jian
Sha, Yan
Wu, Haitao
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To investigate the potential use of indirect computed tomography lymphography (CT-LG) with dendrimer-entrapped gold nanoparticles (Au DENPs) in the localization and enhanced imaging of cervical sentinel lymph node (SLN) on rabbit model.
Methods.
Twelve rabbits were randomly divided into two groups: the positive control group and the experimental group.
In the control group, indirect CT-LG was performed with the injection of 0.5 ml activated carbon nanoparticles (ACNP) and Omnipaque mixture suspension in the right tongue submucosa.
CT images were acquired before the injection and 1, 5, 10, and 15 min after the injection, respectively.
In the experimental group, indirect CT-LG injection with 0.5 ml Au DENPs suspension was performed in the right tongue submucosa.
CT images were obtained before the injection and 1, 5, 10, and 15 min and 1, 2, 6, 24, 48, and 72 h after the injection, respectively.
Then, SLN identification and enhancement characteristics were evaluated.
Results.
Indirect CT-LG revealed the enhancement of one right deep cervical lymph nodes in all animals, which was SLN.
SLN location was marked with black color (ACNP dye) or purple-black color (Au DENPs dye).
At each detection time point, the enhanced SLN attenuation values of control rabbits were statistically significantly higher than that of the plain scan, respectively ( P < 0.05 ).
Also the values of experimental rabbits were statistically significantly higher than that of the control at the same time point after injection ( P < 0.05 ).
The detection rate of SLN was 100%.
Conclusions.
Indirect CT-LG with injection of Au DENPs as CT contrast agents can locate the SLN for a long period of time and enrich the SLN black dye.
It is helpful for SLNs identification during the operation.
American Psychological Association (APA)
Shi, Fang& Yang, Yue& Chen, Jian& Sha, Yan& Shu, Yilai& Wu, Haitao. 2018. Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1124172
Modern Language Association (MLA)
Shi, Fang…[et al.]. Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1124172
American Medical Association (AMA)
Shi, Fang& Yang, Yue& Chen, Jian& Sha, Yan& Shu, Yilai& Wu, Haitao. Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1124172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124172