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Effects of IL-4-590CT (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects
المؤلفون المشاركون
Chen, Guangyuan
Hu, Cong
Song, Yuxuan
Zhang, Haifei
Li, Song
Lai, Penghui
Zhang, Yiling
Huang, Peng
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-02
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Several previous studies have assessed the relationship between IL-4-590C/T gene polymorphism and smoking-related cancer in recent years; however, the results remain controversial.
Based on it, the study intends to clarify whether IL-4-590C/T variant increases the risk of smoking-related cancer through meta-analysis.
Methods.
We searched PubMed, EMBASE, Web of Science, Cochrane Library database, China National Knowledge Infrastructure, and Wanfang data information service platform to collect qualified case-control studies in strict accordance with the inclusion and exclusion standards.
The 95% confidence interval (95% CI) and its odds ratio (OR) were adopted to access the relation between IL-4-590C/T gene polymorphism and smoking-related cancer; sensitivity analysis and publication bias assessment were carried out after the studies’ quality evaluation.
Results.
17 studies were included in total, with 5,061 patients and 6,346 control cases.
A significant association between IL-4-590C/T variant and smoking-related cancer in total population was revealed in our meta-analysis results, and IL-4-590C/T variant might have a relatively protective effect on smoking-related cancer (CT vs.
TT: P=0.026, OR = 0.900, 95% CI: 0.820–0.987).
Subgroup analysis by ethnicity showed that the IL-4-590C/T polymorphism was associated with a decreased risk of smoking-related cancer in the Asian population (CT vs.
TT: P=0.008, OR = 0.878, 95% CI: 0.798–0.967; CC + CT vs.
TT: P=0.030, OR = 0.903, 95% CI: 0.824–0.990).
Subgroup analysis based on types of cancer demonstrated the IL-4-590C/T variant achieved a lower risk in renal cell cancer (CC vs.
TT: P=0.046, OR = 0.640, 95% CI: 0.412–0.993).
Conclusion.
There is a conspicuous association between IL-4-590C/T polymorphism and decreased risk of smoking-related cancer, particularly in Asians.
And IL-4-590C/T polymorphism may have a protective effect on renal cell cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Guangyuan& Hu, Cong& Song, Yuxuan& Zhang, Haifei& Li, Song& Lai, Penghui…[et al.]. 2019. Effects of IL-4-590CT (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1124359
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Guangyuan…[et al.]. Effects of IL-4-590CT (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1124359
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Guangyuan& Hu, Cong& Song, Yuxuan& Zhang, Haifei& Li, Song& Lai, Penghui…[et al.]. Effects of IL-4-590CT (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1124359
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124359
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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