Effects of IL-4-590CT (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects
المؤلفون المشاركون
Chen, Guangyuan
Hu, Cong
Song, Yuxuan
Zhang, Haifei
Li, Song
Lai, Penghui
Zhang, Yiling
Huang, Peng
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-02
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Several previous studies have assessed the relationship between IL-4-590C/T gene polymorphism and smoking-related cancer in recent years; however, the results remain controversial.
Based on it, the study intends to clarify whether IL-4-590C/T variant increases the risk of smoking-related cancer through meta-analysis.
Methods.
We searched PubMed, EMBASE, Web of Science, Cochrane Library database, China National Knowledge Infrastructure, and Wanfang data information service platform to collect qualified case-control studies in strict accordance with the inclusion and exclusion standards.
The 95% confidence interval (95% CI) and its odds ratio (OR) were adopted to access the relation between IL-4-590C/T gene polymorphism and smoking-related cancer; sensitivity analysis and publication bias assessment were carried out after the studies’ quality evaluation.
Results.
17 studies were included in total, with 5,061 patients and 6,346 control cases.
A significant association between IL-4-590C/T variant and smoking-related cancer in total population was revealed in our meta-analysis results, and IL-4-590C/T variant might have a relatively protective effect on smoking-related cancer (CT vs.
TT: P=0.026, OR = 0.900, 95% CI: 0.820–0.987).
Subgroup analysis by ethnicity showed that the IL-4-590C/T polymorphism was associated with a decreased risk of smoking-related cancer in the Asian population (CT vs.
TT: P=0.008, OR = 0.878, 95% CI: 0.798–0.967; CC + CT vs.
TT: P=0.030, OR = 0.903, 95% CI: 0.824–0.990).
Subgroup analysis based on types of cancer demonstrated the IL-4-590C/T variant achieved a lower risk in renal cell cancer (CC vs.
TT: P=0.046, OR = 0.640, 95% CI: 0.412–0.993).
Conclusion.
There is a conspicuous association between IL-4-590C/T polymorphism and decreased risk of smoking-related cancer, particularly in Asians.
And IL-4-590C/T polymorphism may have a protective effect on renal cell cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Guangyuan& Hu, Cong& Song, Yuxuan& Zhang, Haifei& Li, Song& Lai, Penghui…[et al.]. 2019. Effects of IL-4-590CT (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1124359
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Guangyuan…[et al.]. Effects of IL-4-590CT (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1124359
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Guangyuan& Hu, Cong& Song, Yuxuan& Zhang, Haifei& Li, Song& Lai, Penghui…[et al.]. Effects of IL-4-590CT (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1124359
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124359
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر