Effects of IL-4-590CT (rs2243250)‎ Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects

Abstract EN

Background.

Several previous studies have assessed the relationship between IL-4-590C/T gene polymorphism and smoking-related cancer in recent years; however, the results remain controversial.

Based on it, the study intends to clarify whether IL-4-590C/T variant increases the risk of smoking-related cancer through meta-analysis.

Methods.

We searched PubMed, EMBASE, Web of Science, Cochrane Library database, China National Knowledge Infrastructure, and Wanfang data information service platform to collect qualified case-control studies in strict accordance with the inclusion and exclusion standards.

The 95% confidence interval (95% CI) and its odds ratio (OR) were adopted to access the relation between IL-4-590C/T gene polymorphism and smoking-related cancer; sensitivity analysis and publication bias assessment were carried out after the studies’ quality evaluation.

Results.

17 studies were included in total, with 5,061 patients and 6,346 control cases.

A significant association between IL-4-590C/T variant and smoking-related cancer in total population was revealed in our meta-analysis results, and IL-4-590C/T variant might have a relatively protective effect on smoking-related cancer (CT vs.

TT: P=0.026, OR = 0.900, 95% CI: 0.820–0.987).

Subgroup analysis by ethnicity showed that the IL-4-590C/T polymorphism was associated with a decreased risk of smoking-related cancer in the Asian population (CT vs.

TT: P=0.008, OR = 0.878, 95% CI: 0.798–0.967; CC + CT vs.

TT: P=0.030, OR = 0.903, 95% CI: 0.824–0.990).

Subgroup analysis based on types of cancer demonstrated the IL-4-590C/T variant achieved a lower risk in renal cell cancer (CC vs.

TT: P=0.046, OR = 0.640, 95% CI: 0.412–0.993).

Conclusion.

There is a conspicuous association between IL-4-590C/T polymorphism and decreased risk of smoking-related cancer, particularly in Asians.

And IL-4-590C/T polymorphism may have a protective effect on renal cell cancer.