Effects of IL-4-590CT (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects
Joint Authors
Chen, Guangyuan
Hu, Cong
Song, Yuxuan
Zhang, Haifei
Li, Song
Lai, Penghui
Zhang, Yiling
Huang, Peng
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Several previous studies have assessed the relationship between IL-4-590C/T gene polymorphism and smoking-related cancer in recent years; however, the results remain controversial.
Based on it, the study intends to clarify whether IL-4-590C/T variant increases the risk of smoking-related cancer through meta-analysis.
Methods.
We searched PubMed, EMBASE, Web of Science, Cochrane Library database, China National Knowledge Infrastructure, and Wanfang data information service platform to collect qualified case-control studies in strict accordance with the inclusion and exclusion standards.
The 95% confidence interval (95% CI) and its odds ratio (OR) were adopted to access the relation between IL-4-590C/T gene polymorphism and smoking-related cancer; sensitivity analysis and publication bias assessment were carried out after the studies’ quality evaluation.
Results.
17 studies were included in total, with 5,061 patients and 6,346 control cases.
A significant association between IL-4-590C/T variant and smoking-related cancer in total population was revealed in our meta-analysis results, and IL-4-590C/T variant might have a relatively protective effect on smoking-related cancer (CT vs.
TT: P=0.026, OR = 0.900, 95% CI: 0.820–0.987).
Subgroup analysis by ethnicity showed that the IL-4-590C/T polymorphism was associated with a decreased risk of smoking-related cancer in the Asian population (CT vs.
TT: P=0.008, OR = 0.878, 95% CI: 0.798–0.967; CC + CT vs.
TT: P=0.030, OR = 0.903, 95% CI: 0.824–0.990).
Subgroup analysis based on types of cancer demonstrated the IL-4-590C/T variant achieved a lower risk in renal cell cancer (CC vs.
TT: P=0.046, OR = 0.640, 95% CI: 0.412–0.993).
Conclusion.
There is a conspicuous association between IL-4-590C/T polymorphism and decreased risk of smoking-related cancer, particularly in Asians.
And IL-4-590C/T polymorphism may have a protective effect on renal cell cancer.
American Psychological Association (APA)
Chen, Guangyuan& Hu, Cong& Song, Yuxuan& Zhang, Haifei& Li, Song& Lai, Penghui…[et al.]. 2019. Effects of IL-4-590CT (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1124359
Modern Language Association (MLA)
Chen, Guangyuan…[et al.]. Effects of IL-4-590CT (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1124359
American Medical Association (AMA)
Chen, Guangyuan& Hu, Cong& Song, Yuxuan& Zhang, Haifei& Li, Song& Lai, Penghui…[et al.]. Effects of IL-4-590CT (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1124359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124359