Pharmacokinetic Study of Delavinone in Mice after Intravenous and Oral Administration by UPLC-MSMS
المؤلفون المشاركون
Wang, Shuang-Hu
Zhang, Zhiguang
Yu, Zheng
Han, Cheng
Wang, Xianqin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Thirty-one compounds, including delavinone, were isolated from the methanol extract of F.
cirrhosa by modern chromatographic techniques.
The pharmacological action of Fritillaria is widely used in clinical practice.
However, the pharmacokinetic studies on delavinone have not been reported.
Therefore, the chemical constituents of this species were investigated.
Therefore, it is necessary to establish an analytical method to monitor the concentration of delavinone.
An UPLC-MS/MS method was established to determine delavinone in the mouse blood, and the pharmacokinetics of delavinone after intravenous (1.0 mg/kg) and intragastric (2.5, 10.0 mg/kg) administration were studied.
The lower limit of quantification was 1.0 ng/mL.
The intraday and interday precision RSD were less than 13%, the accuracy ranged from 96.8% to 104.9%, the average recovery was better than 80.6%, and the matrix effect was between 88.8% and 103.4%.
The UPLC-MS/MS method has been successfully applied to the pharmacokinetics of delavinone in mice.
The noncompartment model was used to fit the main pharmacokinetic parameters.
It was found that AUC in mice was higher than that in mice given orally, and the bioavailability of delavinone was 12.4%.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Shuang-Hu& Zhang, Zhiguang& Yu, Zheng& Han, Cheng& Wang, Xianqin. 2019. Pharmacokinetic Study of Delavinone in Mice after Intravenous and Oral Administration by UPLC-MSMS. BioMed Research International،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1124405
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Shuang-Hu…[et al.]. Pharmacokinetic Study of Delavinone in Mice after Intravenous and Oral Administration by UPLC-MSMS. BioMed Research International No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1124405
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Shuang-Hu& Zhang, Zhiguang& Yu, Zheng& Han, Cheng& Wang, Xianqin. Pharmacokinetic Study of Delavinone in Mice after Intravenous and Oral Administration by UPLC-MSMS. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1124405
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124405
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر