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Pharmacokinetic Study of Delavinone in Mice after Intravenous and Oral Administration by UPLC-MSMS
Joint Authors
Wang, Shuang-Hu
Zhang, Zhiguang
Yu, Zheng
Han, Cheng
Wang, Xianqin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Thirty-one compounds, including delavinone, were isolated from the methanol extract of F.
cirrhosa by modern chromatographic techniques.
The pharmacological action of Fritillaria is widely used in clinical practice.
However, the pharmacokinetic studies on delavinone have not been reported.
Therefore, the chemical constituents of this species were investigated.
Therefore, it is necessary to establish an analytical method to monitor the concentration of delavinone.
An UPLC-MS/MS method was established to determine delavinone in the mouse blood, and the pharmacokinetics of delavinone after intravenous (1.0 mg/kg) and intragastric (2.5, 10.0 mg/kg) administration were studied.
The lower limit of quantification was 1.0 ng/mL.
The intraday and interday precision RSD were less than 13%, the accuracy ranged from 96.8% to 104.9%, the average recovery was better than 80.6%, and the matrix effect was between 88.8% and 103.4%.
The UPLC-MS/MS method has been successfully applied to the pharmacokinetics of delavinone in mice.
The noncompartment model was used to fit the main pharmacokinetic parameters.
It was found that AUC in mice was higher than that in mice given orally, and the bioavailability of delavinone was 12.4%.
American Psychological Association (APA)
Wang, Shuang-Hu& Zhang, Zhiguang& Yu, Zheng& Han, Cheng& Wang, Xianqin. 2019. Pharmacokinetic Study of Delavinone in Mice after Intravenous and Oral Administration by UPLC-MSMS. BioMed Research International،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1124405
Modern Language Association (MLA)
Wang, Shuang-Hu…[et al.]. Pharmacokinetic Study of Delavinone in Mice after Intravenous and Oral Administration by UPLC-MSMS. BioMed Research International No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1124405
American Medical Association (AMA)
Wang, Shuang-Hu& Zhang, Zhiguang& Yu, Zheng& Han, Cheng& Wang, Xianqin. Pharmacokinetic Study of Delavinone in Mice after Intravenous and Oral Administration by UPLC-MSMS. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1124405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124405