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Luteinizing HormoneHuman Chorionic Gonadotropin Receptor Immunohistochemical Score Associated with Poor Prognosis in Endometrial Cancer Patients
المؤلفون المشاركون
Pillozzi, Serena
Castiglione, F.
Sorbi, Flavia
Projetto, Elisabetta
Turrini, Irene
Baroni, Gianna
Ghizzoni, Viola
Vergoni, Federica
Malentacchi, Francesca
Noci, I.
Fambrini, Massimiliano
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-02
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The aim of this study was to develop a scoring system of the immunohistochemical (IHC) expression of luteinizing hormone/human chorionic gonadotropin receptor (LHCG-R) in endometrial cancer (EC) patients.
Nonconsecutive hysterectomy specimens containing EC collected from April 2013 to October 2015 were selected.
Hematoxylin-eosin stained sections from each case were reviewed and representative sections from each tumor were selected.
IHC staining was performed for the detection of LHCG-R.
The percentage of stained cells and the staining intensity were assessed in order to develop an immunohistochemical score.
Moreover, we examined the correlation of the score with grading and lymphovascular space invasion (LVSI).
There was a statistically significant positive correlation between grading and IHC scoring (p=0.01) and a statistically significant positive correlation between LVSI and IHC score (p<0.01).
In conclusion, we suggest that the immunohistochemical score presented here could be used as a marker of bad prognosis of EC patients.
Nevertheless, further studies are needed in order to validate it.
The study was registered in the Careggi Hospital public trials registry with the following number: 2013/0011391.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sorbi, Flavia& Projetto, Elisabetta& Turrini, Irene& Baroni, Gianna& Pillozzi, Serena& Ghizzoni, Viola…[et al.]. 2018. Luteinizing HormoneHuman Chorionic Gonadotropin Receptor Immunohistochemical Score Associated with Poor Prognosis in Endometrial Cancer Patients. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1124516
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sorbi, Flavia…[et al.]. Luteinizing HormoneHuman Chorionic Gonadotropin Receptor Immunohistochemical Score Associated with Poor Prognosis in Endometrial Cancer Patients. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1124516
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sorbi, Flavia& Projetto, Elisabetta& Turrini, Irene& Baroni, Gianna& Pillozzi, Serena& Ghizzoni, Viola…[et al.]. Luteinizing HormoneHuman Chorionic Gonadotropin Receptor Immunohistochemical Score Associated with Poor Prognosis in Endometrial Cancer Patients. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1124516
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124516
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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