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Luteinizing HormoneHuman Chorionic Gonadotropin Receptor Immunohistochemical Score Associated with Poor Prognosis in Endometrial Cancer Patients
Joint Authors
Pillozzi, Serena
Castiglione, F.
Sorbi, Flavia
Projetto, Elisabetta
Turrini, Irene
Baroni, Gianna
Ghizzoni, Viola
Vergoni, Federica
Malentacchi, Francesca
Noci, I.
Fambrini, Massimiliano
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this study was to develop a scoring system of the immunohistochemical (IHC) expression of luteinizing hormone/human chorionic gonadotropin receptor (LHCG-R) in endometrial cancer (EC) patients.
Nonconsecutive hysterectomy specimens containing EC collected from April 2013 to October 2015 were selected.
Hematoxylin-eosin stained sections from each case were reviewed and representative sections from each tumor were selected.
IHC staining was performed for the detection of LHCG-R.
The percentage of stained cells and the staining intensity were assessed in order to develop an immunohistochemical score.
Moreover, we examined the correlation of the score with grading and lymphovascular space invasion (LVSI).
There was a statistically significant positive correlation between grading and IHC scoring (p=0.01) and a statistically significant positive correlation between LVSI and IHC score (p<0.01).
In conclusion, we suggest that the immunohistochemical score presented here could be used as a marker of bad prognosis of EC patients.
Nevertheless, further studies are needed in order to validate it.
The study was registered in the Careggi Hospital public trials registry with the following number: 2013/0011391.
American Psychological Association (APA)
Sorbi, Flavia& Projetto, Elisabetta& Turrini, Irene& Baroni, Gianna& Pillozzi, Serena& Ghizzoni, Viola…[et al.]. 2018. Luteinizing HormoneHuman Chorionic Gonadotropin Receptor Immunohistochemical Score Associated with Poor Prognosis in Endometrial Cancer Patients. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1124516
Modern Language Association (MLA)
Sorbi, Flavia…[et al.]. Luteinizing HormoneHuman Chorionic Gonadotropin Receptor Immunohistochemical Score Associated with Poor Prognosis in Endometrial Cancer Patients. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1124516
American Medical Association (AMA)
Sorbi, Flavia& Projetto, Elisabetta& Turrini, Irene& Baroni, Gianna& Pillozzi, Serena& Ghizzoni, Viola…[et al.]. Luteinizing HormoneHuman Chorionic Gonadotropin Receptor Immunohistochemical Score Associated with Poor Prognosis in Endometrial Cancer Patients. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1124516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124516