Transient Elastography and Ultrasonography: Optimal Evaluation of Liver Fibrosis and Cirrhosis in Patients with Chronic Hepatitis B Concurrent with Nonalcoholic Fatty Liver Disease
المؤلفون المشاركون
Gao, Zhiliang
Zhao, Qiyi
Zhang, Geng-lin
Lin, Chao-shuang
Hu, Zhao-xia
Zhang, Ting
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background and Aims.
Concordance between transient elastography (TE) and ultrasonography (US) in assessing liver fibrosis in patients with chronic hepatitis B (CHB) and concurrent nonalcoholic fatty liver disease (NAFLD) has been rarely studied.
This study aimed to evaluate the individual and combined performances of TE and US in assessing liver fibrosis and cirrhosis.
Patients and Methods.
Consecutive CHB patients with NAFLD were prospectively enrolled.
TE and US examinations were performed, with liver biopsy as a reference standard.
Receiver operating characteristic (ROC) curves were obtained to evaluate the diagnostic performance.
Differences between the areas under the ROC curves (AUCs) were compared using DeLong’s test.
Results.
TE and US scores correlated significantly with the histological fibrosis staging scores.
TE was significantly superior to US in the diagnosis of significant fibrosis (AUC, 0.84 vs 0.73; P=0.02), advanced fibrosis (AUC, 0.95 vs 0.76; P<0.001), and cirrhosis (AUC, 0.96 vs 0.71; P<0.001).
Combining TE with US did not increase the accuracy of detecting significant fibrosis, advanced cirrhosis, or cirrhosis (P=0.62, P=0.69, and P=0.38, respectively) compared to TE alone.
However, TE combined with US significantly increased the positive predictive value for significant fibrosis when compared to TE alone.
The optimal cut-off values of TE for predicting advanced fibrosis and cirrhosis were 8.7 kPa and 10.9 kPa, with negative predictive values of 92.4% and 98.7%, respectively.
Conclusions.
TE is useful for predicting hepatic fibrosis and excluding cirrhosis in CHB patients with NAFLD.
A combination of TE and US does not improve the accuracy in assessing liver fibrosis or cirrhosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Geng-lin& Zhao, Qiyi& Lin, Chao-shuang& Hu, Zhao-xia& Zhang, Ting& Gao, Zhiliang. 2019. Transient Elastography and Ultrasonography: Optimal Evaluation of Liver Fibrosis and Cirrhosis in Patients with Chronic Hepatitis B Concurrent with Nonalcoholic Fatty Liver Disease. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125011
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Geng-lin…[et al.]. Transient Elastography and Ultrasonography: Optimal Evaluation of Liver Fibrosis and Cirrhosis in Patients with Chronic Hepatitis B Concurrent with Nonalcoholic Fatty Liver Disease. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1125011
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Geng-lin& Zhao, Qiyi& Lin, Chao-shuang& Hu, Zhao-xia& Zhang, Ting& Gao, Zhiliang. Transient Elastography and Ultrasonography: Optimal Evaluation of Liver Fibrosis and Cirrhosis in Patients with Chronic Hepatitis B Concurrent with Nonalcoholic Fatty Liver Disease. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125011
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125011
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر