Transient Elastography and Ultrasonography: Optimal Evaluation of Liver Fibrosis and Cirrhosis in Patients with Chronic Hepatitis B Concurrent with Nonalcoholic Fatty Liver Disease
Joint Authors
Gao, Zhiliang
Zhao, Qiyi
Zhang, Geng-lin
Lin, Chao-shuang
Hu, Zhao-xia
Zhang, Ting
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background and Aims.
Concordance between transient elastography (TE) and ultrasonography (US) in assessing liver fibrosis in patients with chronic hepatitis B (CHB) and concurrent nonalcoholic fatty liver disease (NAFLD) has been rarely studied.
This study aimed to evaluate the individual and combined performances of TE and US in assessing liver fibrosis and cirrhosis.
Patients and Methods.
Consecutive CHB patients with NAFLD were prospectively enrolled.
TE and US examinations were performed, with liver biopsy as a reference standard.
Receiver operating characteristic (ROC) curves were obtained to evaluate the diagnostic performance.
Differences between the areas under the ROC curves (AUCs) were compared using DeLong’s test.
Results.
TE and US scores correlated significantly with the histological fibrosis staging scores.
TE was significantly superior to US in the diagnosis of significant fibrosis (AUC, 0.84 vs 0.73; P=0.02), advanced fibrosis (AUC, 0.95 vs 0.76; P<0.001), and cirrhosis (AUC, 0.96 vs 0.71; P<0.001).
Combining TE with US did not increase the accuracy of detecting significant fibrosis, advanced cirrhosis, or cirrhosis (P=0.62, P=0.69, and P=0.38, respectively) compared to TE alone.
However, TE combined with US significantly increased the positive predictive value for significant fibrosis when compared to TE alone.
The optimal cut-off values of TE for predicting advanced fibrosis and cirrhosis were 8.7 kPa and 10.9 kPa, with negative predictive values of 92.4% and 98.7%, respectively.
Conclusions.
TE is useful for predicting hepatic fibrosis and excluding cirrhosis in CHB patients with NAFLD.
A combination of TE and US does not improve the accuracy in assessing liver fibrosis or cirrhosis.
American Psychological Association (APA)
Zhang, Geng-lin& Zhao, Qiyi& Lin, Chao-shuang& Hu, Zhao-xia& Zhang, Ting& Gao, Zhiliang. 2019. Transient Elastography and Ultrasonography: Optimal Evaluation of Liver Fibrosis and Cirrhosis in Patients with Chronic Hepatitis B Concurrent with Nonalcoholic Fatty Liver Disease. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125011
Modern Language Association (MLA)
Zhang, Geng-lin…[et al.]. Transient Elastography and Ultrasonography: Optimal Evaluation of Liver Fibrosis and Cirrhosis in Patients with Chronic Hepatitis B Concurrent with Nonalcoholic Fatty Liver Disease. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1125011
American Medical Association (AMA)
Zhang, Geng-lin& Zhao, Qiyi& Lin, Chao-shuang& Hu, Zhao-xia& Zhang, Ting& Gao, Zhiliang. Transient Elastography and Ultrasonography: Optimal Evaluation of Liver Fibrosis and Cirrhosis in Patients with Chronic Hepatitis B Concurrent with Nonalcoholic Fatty Liver Disease. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125011
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125011