Impaired Gut Epithelial Tight Junction Expression in Hemodialysis Patients Complicated with Intradialytic Hypotension
المؤلفون المشاركون
Lim, Paik Seong
Wu, Tsai-Kun
Jin, Jong-Shiaw
Wu, Ming-Ying
Chen, Chang-Hsu
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
There is accumulating evidence pointing to uremia-induced impairment of the intestinal epithelial barrier structure in advanced chronic kidney disease (CKD) and hemodialysis (HD) patients.
In this study, the impact of intradialytic hypotension on intestinal barrier integrity is being explored.
Methods.
Immunohistochemical staining was used to detect the expression of 4 types of tight junction (TJ) proteins such as occludin, zonula occludens-1 (ZO-1), claudin-1, and claudin-4, in colonic samples of a group of patients receiving segmental colectomy.
Five patients with nondialysis CKD (group 2), 5 HD patients with intradialytic hypotension (group 3), and 5 non-CKD subjects (group 1) were examined.
Results.
Both patients’ groups 2 and 3 demonstrated significantly reduced expression of occludin as compared to group 1 (p<0.05 and p<0.01, resp.).
Except for claudin-4, expression of all markers of TJ proteins was significantly reduced in patients’ group 3 as compared to control (p<0.01).
In addition, decreased expressions of claudin-1 and ZO-1 were also more pronounced in group 3 when compared to group 2.
Conclusions.
This study extends the earlier finding by demonstrating that dialysis-related hypotension caused even marked depletion of the key protein constituents of the epithelial TJ.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Tsai-Kun& Lim, Paik Seong& Jin, Jong-Shiaw& Wu, Ming-Ying& Chen, Chang-Hsu. 2018. Impaired Gut Epithelial Tight Junction Expression in Hemodialysis Patients Complicated with Intradialytic Hypotension. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125195
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Tsai-Kun…[et al.]. Impaired Gut Epithelial Tight Junction Expression in Hemodialysis Patients Complicated with Intradialytic Hypotension. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1125195
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Tsai-Kun& Lim, Paik Seong& Jin, Jong-Shiaw& Wu, Ming-Ying& Chen, Chang-Hsu. Impaired Gut Epithelial Tight Junction Expression in Hemodialysis Patients Complicated with Intradialytic Hypotension. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125195
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125195
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر