Impaired Gut Epithelial Tight Junction Expression in Hemodialysis Patients Complicated with Intradialytic Hypotension
Joint Authors
Lim, Paik Seong
Wu, Tsai-Kun
Jin, Jong-Shiaw
Wu, Ming-Ying
Chen, Chang-Hsu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
There is accumulating evidence pointing to uremia-induced impairment of the intestinal epithelial barrier structure in advanced chronic kidney disease (CKD) and hemodialysis (HD) patients.
In this study, the impact of intradialytic hypotension on intestinal barrier integrity is being explored.
Methods.
Immunohistochemical staining was used to detect the expression of 4 types of tight junction (TJ) proteins such as occludin, zonula occludens-1 (ZO-1), claudin-1, and claudin-4, in colonic samples of a group of patients receiving segmental colectomy.
Five patients with nondialysis CKD (group 2), 5 HD patients with intradialytic hypotension (group 3), and 5 non-CKD subjects (group 1) were examined.
Results.
Both patients’ groups 2 and 3 demonstrated significantly reduced expression of occludin as compared to group 1 (p<0.05 and p<0.01, resp.).
Except for claudin-4, expression of all markers of TJ proteins was significantly reduced in patients’ group 3 as compared to control (p<0.01).
In addition, decreased expressions of claudin-1 and ZO-1 were also more pronounced in group 3 when compared to group 2.
Conclusions.
This study extends the earlier finding by demonstrating that dialysis-related hypotension caused even marked depletion of the key protein constituents of the epithelial TJ.
American Psychological Association (APA)
Wu, Tsai-Kun& Lim, Paik Seong& Jin, Jong-Shiaw& Wu, Ming-Ying& Chen, Chang-Hsu. 2018. Impaired Gut Epithelial Tight Junction Expression in Hemodialysis Patients Complicated with Intradialytic Hypotension. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125195
Modern Language Association (MLA)
Wu, Tsai-Kun…[et al.]. Impaired Gut Epithelial Tight Junction Expression in Hemodialysis Patients Complicated with Intradialytic Hypotension. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1125195
American Medical Association (AMA)
Wu, Tsai-Kun& Lim, Paik Seong& Jin, Jong-Shiaw& Wu, Ming-Ying& Chen, Chang-Hsu. Impaired Gut Epithelial Tight Junction Expression in Hemodialysis Patients Complicated with Intradialytic Hypotension. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1125195
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125195