Efficacy and Safety of Different Norepinephrine Regimens for Prevention of Spinal Hypotension in Cesarean Section: A Randomized Trial
المؤلفون المشاركون
Chen, Daili
Qi, Xiaofei
Huang, Xiaolei
Xu, Yang
Qiu, Feilong
Yan, Yuting
Li, Yuantao
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The aim of this paper is to evaluate the efficacy and safety of three different norepinephrine dosing regimens for preventing spinal hypotension in cesarean section.
In this randomized double-blinded controlled study, 120 parturients scheduled for elective section delivery under spinal anesthesia were assigned to 1 of 4 groups.
In the control group, patients received saline infusion.
In three norepinephrine groups, the infusion dosage regimens were 5, 10, and 15 μg/kg/h, respectively.
Hypotension was treated with a rescue bolus of 10 μg norepinephrine.
The study protocol was continued until the end of surgery.
The primary outcome was the proportion of participants that underwent hypotension.
The proportion of hypotension participants was significantly reduced in the norepinephrine groups (37.9%, 20%, and 25%, respectively) compared to that in the control group (86.7%).
However, the highest dose of norepinephrine (15 μg/kg/h) resulted in more hypertension episodes.
In addition, blood pressure was better maintained in the norepinephrine 5 μg/kg/h and 10 μg/kg/h groups than in the control group and 15 μg/kg/h group.
No significant differences in other hemodynamic variables, adverse effects, maternal and neonatal blood gases, or Apgar scores were observed among the groups.
In summary, for patients who undergo cesarean delivery under spinal anesthesia, infusion of 5–10 μg/kg/h norepinephrine was effective to reduce hypotension incidence without significant adverse effects on maternal and neonatal outcomes.
Clinical Trial Registration Number is ChiCTR-INR-16009452.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Daili& Qi, Xiaofei& Huang, Xiaolei& Xu, Yang& Qiu, Feilong& Yan, Yuting…[et al.]. 2018. Efficacy and Safety of Different Norepinephrine Regimens for Prevention of Spinal Hypotension in Cesarean Section: A Randomized Trial. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125245
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Daili…[et al.]. Efficacy and Safety of Different Norepinephrine Regimens for Prevention of Spinal Hypotension in Cesarean Section: A Randomized Trial. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1125245
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Daili& Qi, Xiaofei& Huang, Xiaolei& Xu, Yang& Qiu, Feilong& Yan, Yuting…[et al.]. Efficacy and Safety of Different Norepinephrine Regimens for Prevention of Spinal Hypotension in Cesarean Section: A Randomized Trial. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125245
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125245
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر