Efficacy and Safety of Different Norepinephrine Regimens for Prevention of Spinal Hypotension in Cesarean Section: A Randomized Trial

المؤلفون المشاركون

Chen, Daili
Qi, Xiaofei
Huang, Xiaolei
Xu, Yang
Qiu, Feilong
Yan, Yuting
Li, Yuantao

المصدر

BioMed Research International

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-05-23

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

The aim of this paper is to evaluate the efficacy and safety of three different norepinephrine dosing regimens for preventing spinal hypotension in cesarean section.

In this randomized double-blinded controlled study, 120 parturients scheduled for elective section delivery under spinal anesthesia were assigned to 1 of 4 groups.

In the control group, patients received saline infusion.

In three norepinephrine groups, the infusion dosage regimens were 5, 10, and 15 μg/kg/h, respectively.

Hypotension was treated with a rescue bolus of 10 μg norepinephrine.

The study protocol was continued until the end of surgery.

The primary outcome was the proportion of participants that underwent hypotension.

The proportion of hypotension participants was significantly reduced in the norepinephrine groups (37.9%, 20%, and 25%, respectively) compared to that in the control group (86.7%).

However, the highest dose of norepinephrine (15 μg/kg/h) resulted in more hypertension episodes.

In addition, blood pressure was better maintained in the norepinephrine 5 μg/kg/h and 10 μg/kg/h groups than in the control group and 15 μg/kg/h group.

No significant differences in other hemodynamic variables, adverse effects, maternal and neonatal blood gases, or Apgar scores were observed among the groups.

In summary, for patients who undergo cesarean delivery under spinal anesthesia, infusion of 5–10 μg/kg/h norepinephrine was effective to reduce hypotension incidence without significant adverse effects on maternal and neonatal outcomes.

Clinical Trial Registration Number is ChiCTR-INR-16009452.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Chen, Daili& Qi, Xiaofei& Huang, Xiaolei& Xu, Yang& Qiu, Feilong& Yan, Yuting…[et al.]. 2018. Efficacy and Safety of Different Norepinephrine Regimens for Prevention of Spinal Hypotension in Cesarean Section: A Randomized Trial. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125245

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Chen, Daili…[et al.]. Efficacy and Safety of Different Norepinephrine Regimens for Prevention of Spinal Hypotension in Cesarean Section: A Randomized Trial. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1125245

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Chen, Daili& Qi, Xiaofei& Huang, Xiaolei& Xu, Yang& Qiu, Feilong& Yan, Yuting…[et al.]. Efficacy and Safety of Different Norepinephrine Regimens for Prevention of Spinal Hypotension in Cesarean Section: A Randomized Trial. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125245

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1125245