Efficacy and Safety of Different Norepinephrine Regimens for Prevention of Spinal Hypotension in Cesarean Section: A Randomized Trial
Joint Authors
Chen, Daili
Qi, Xiaofei
Huang, Xiaolei
Xu, Yang
Qiu, Feilong
Yan, Yuting
Li, Yuantao
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this paper is to evaluate the efficacy and safety of three different norepinephrine dosing regimens for preventing spinal hypotension in cesarean section.
In this randomized double-blinded controlled study, 120 parturients scheduled for elective section delivery under spinal anesthesia were assigned to 1 of 4 groups.
In the control group, patients received saline infusion.
In three norepinephrine groups, the infusion dosage regimens were 5, 10, and 15 μg/kg/h, respectively.
Hypotension was treated with a rescue bolus of 10 μg norepinephrine.
The study protocol was continued until the end of surgery.
The primary outcome was the proportion of participants that underwent hypotension.
The proportion of hypotension participants was significantly reduced in the norepinephrine groups (37.9%, 20%, and 25%, respectively) compared to that in the control group (86.7%).
However, the highest dose of norepinephrine (15 μg/kg/h) resulted in more hypertension episodes.
In addition, blood pressure was better maintained in the norepinephrine 5 μg/kg/h and 10 μg/kg/h groups than in the control group and 15 μg/kg/h group.
No significant differences in other hemodynamic variables, adverse effects, maternal and neonatal blood gases, or Apgar scores were observed among the groups.
In summary, for patients who undergo cesarean delivery under spinal anesthesia, infusion of 5–10 μg/kg/h norepinephrine was effective to reduce hypotension incidence without significant adverse effects on maternal and neonatal outcomes.
Clinical Trial Registration Number is ChiCTR-INR-16009452.
American Psychological Association (APA)
Chen, Daili& Qi, Xiaofei& Huang, Xiaolei& Xu, Yang& Qiu, Feilong& Yan, Yuting…[et al.]. 2018. Efficacy and Safety of Different Norepinephrine Regimens for Prevention of Spinal Hypotension in Cesarean Section: A Randomized Trial. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125245
Modern Language Association (MLA)
Chen, Daili…[et al.]. Efficacy and Safety of Different Norepinephrine Regimens for Prevention of Spinal Hypotension in Cesarean Section: A Randomized Trial. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1125245
American Medical Association (AMA)
Chen, Daili& Qi, Xiaofei& Huang, Xiaolei& Xu, Yang& Qiu, Feilong& Yan, Yuting…[et al.]. Efficacy and Safety of Different Norepinephrine Regimens for Prevention of Spinal Hypotension in Cesarean Section: A Randomized Trial. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125245