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Identification of Feline Interferon Regulatory Factor 1 as an Efficient Antiviral Factor against the Replication of Feline Calicivirus and Other Feline Viruses
المؤلفون المشاركون
Liu, Yongxiang
Liu, Xiaoxiao
Kang, Hongtao
Hu, Xiaoliang
Liu, Jiasen
Tian, Jin
Qu, Liandong
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Interferons (IFNs) can inhibit most, if not all, viral infections by eliciting the transcription of hundreds of interferon-stimulated genes (ISGs).
Feline calicivirus (FCV) is a highly contagious pathogen of cats and a surrogate for Norwalk virus.
Interferon efficiently inhibits the replication of FCV, but the mechanism of the antiviral activity is poorly understood.
Here, we evaluated the anti-FCV activity of ten ISGs, whose antiviral activities were previously reported.
The results showed that interferon regulatory factor 1 (IRF1) can significantly inhibit the replication of FCV, whereas the other ISGs tested in this study failed.
Further, we found that IRF1 was localized in the nucleus and efficiently activated IFN-β and the ISRE promoter.
IRF1 can trigger the production of endogenous interferon and the expression of ISGs, suggesting that IRF1 can positively regulate IFN signalling.
Importantly, the mRNA and protein levels of IRF1 were reduced upon FCV infection, which may be a new strategy for FCV to evade the innate immune system.
Finally, the antiviral activity of IRF1 against feline panleukopenia virus, feline herpesvirus, and feline infectious peritonitis virus was demonstrated.
These data indicate that feline IRF1 plays an important role in regulating the host type I IFN response and inhibiting feline viral infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yongxiang& Liu, Xiaoxiao& Kang, Hongtao& Hu, Xiaoliang& Liu, Jiasen& Tian, Jin…[et al.]. 2018. Identification of Feline Interferon Regulatory Factor 1 as an Efficient Antiviral Factor against the Replication of Feline Calicivirus and Other Feline Viruses. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125294
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yongxiang…[et al.]. Identification of Feline Interferon Regulatory Factor 1 as an Efficient Antiviral Factor against the Replication of Feline Calicivirus and Other Feline Viruses. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1125294
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yongxiang& Liu, Xiaoxiao& Kang, Hongtao& Hu, Xiaoliang& Liu, Jiasen& Tian, Jin…[et al.]. Identification of Feline Interferon Regulatory Factor 1 as an Efficient Antiviral Factor against the Replication of Feline Calicivirus and Other Feline Viruses. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125294
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125294
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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