Identification of Feline Interferon Regulatory Factor 1 as an Efficient Antiviral Factor against the Replication of Feline Calicivirus and Other Feline Viruses
Joint Authors
Liu, Yongxiang
Liu, Xiaoxiao
Kang, Hongtao
Hu, Xiaoliang
Liu, Jiasen
Tian, Jin
Qu, Liandong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Interferons (IFNs) can inhibit most, if not all, viral infections by eliciting the transcription of hundreds of interferon-stimulated genes (ISGs).
Feline calicivirus (FCV) is a highly contagious pathogen of cats and a surrogate for Norwalk virus.
Interferon efficiently inhibits the replication of FCV, but the mechanism of the antiviral activity is poorly understood.
Here, we evaluated the anti-FCV activity of ten ISGs, whose antiviral activities were previously reported.
The results showed that interferon regulatory factor 1 (IRF1) can significantly inhibit the replication of FCV, whereas the other ISGs tested in this study failed.
Further, we found that IRF1 was localized in the nucleus and efficiently activated IFN-β and the ISRE promoter.
IRF1 can trigger the production of endogenous interferon and the expression of ISGs, suggesting that IRF1 can positively regulate IFN signalling.
Importantly, the mRNA and protein levels of IRF1 were reduced upon FCV infection, which may be a new strategy for FCV to evade the innate immune system.
Finally, the antiviral activity of IRF1 against feline panleukopenia virus, feline herpesvirus, and feline infectious peritonitis virus was demonstrated.
These data indicate that feline IRF1 plays an important role in regulating the host type I IFN response and inhibiting feline viral infections.
American Psychological Association (APA)
Liu, Yongxiang& Liu, Xiaoxiao& Kang, Hongtao& Hu, Xiaoliang& Liu, Jiasen& Tian, Jin…[et al.]. 2018. Identification of Feline Interferon Regulatory Factor 1 as an Efficient Antiviral Factor against the Replication of Feline Calicivirus and Other Feline Viruses. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125294
Modern Language Association (MLA)
Liu, Yongxiang…[et al.]. Identification of Feline Interferon Regulatory Factor 1 as an Efficient Antiviral Factor against the Replication of Feline Calicivirus and Other Feline Viruses. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1125294
American Medical Association (AMA)
Liu, Yongxiang& Liu, Xiaoxiao& Kang, Hongtao& Hu, Xiaoliang& Liu, Jiasen& Tian, Jin…[et al.]. Identification of Feline Interferon Regulatory Factor 1 as an Efficient Antiviral Factor against the Replication of Feline Calicivirus and Other Feline Viruses. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125294