Serum Metabolomics Analysis of Asthma in Different Inflammatory Phenotypes: A Cross-Sectional Study in Northeast China
المؤلفون المشاركون
Liu, Jinping
Wang, Fang
Zhang, Weijie
Pang, Zhiqiang
Wang, Guoqiang
Wang, Cuizhu
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-23
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background and Objective.
Asthma as a chronic heterogeneous disease seriously affects the quality of life.
Incorrect identification for its clinical phenotypes lead to a huge waste of medical resources.
Metabolomic technique as a novel approach to explore the pathogenesis of diseases have not been used to study asthma based on their clear defined inflammatory phenotypes.
This study is aimed to distinguish the divergent metabolic profile in different asthma phenotypes and clarify the pathogenesis of them.
Methods.
Participants including eosinophilic asthmatics (EA, n=13), noneosinophilic asthmatics (NEA, n=16), and healthy controls (HC, n=15) were enrolled.
A global profile of untargeted serum metabolomics was identified with Ultra Performance Liquid Chromatography–Mass Spectrometry technique.
Results.
Multivariate analysis was performed and showed a clear distinction between EA, NEA, and HC.
A total of 18 different metabolites were recognized between the three groups based on OPLS-DA model and involved in 10 perturbed metabolic pathways.
Glycerophospholipid metabolism, retinol metabolism, and sphingolipid metabolism were identified as the most significant changed three pathways (impact > 0.1 and -log(P) > 4) between the phenotypes.
Conclusions.
We showed that the different inflammatory phenotypes of asthma involve the immune regulation, energy, and nutrients metabolism.
The clarified metabolic profile contributes to understanding the pathophysiology of asthma phenotypes and optimizing the therapeutic strategy against asthma heterogeneity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pang, Zhiqiang& Wang, Guoqiang& Wang, Cuizhu& Zhang, Weijie& Liu, Jinping& Wang, Fang. 2018. Serum Metabolomics Analysis of Asthma in Different Inflammatory Phenotypes: A Cross-Sectional Study in Northeast China. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1125434
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pang, Zhiqiang…[et al.]. Serum Metabolomics Analysis of Asthma in Different Inflammatory Phenotypes: A Cross-Sectional Study in Northeast China. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1125434
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pang, Zhiqiang& Wang, Guoqiang& Wang, Cuizhu& Zhang, Weijie& Liu, Jinping& Wang, Fang. Serum Metabolomics Analysis of Asthma in Different Inflammatory Phenotypes: A Cross-Sectional Study in Northeast China. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1125434
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125434
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر