Serum Metabolomics Analysis of Asthma in Different Inflammatory Phenotypes: A Cross-Sectional Study in Northeast China
Joint Authors
Liu, Jinping
Wang, Fang
Zhang, Weijie
Pang, Zhiqiang
Wang, Guoqiang
Wang, Cuizhu
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background and Objective.
Asthma as a chronic heterogeneous disease seriously affects the quality of life.
Incorrect identification for its clinical phenotypes lead to a huge waste of medical resources.
Metabolomic technique as a novel approach to explore the pathogenesis of diseases have not been used to study asthma based on their clear defined inflammatory phenotypes.
This study is aimed to distinguish the divergent metabolic profile in different asthma phenotypes and clarify the pathogenesis of them.
Methods.
Participants including eosinophilic asthmatics (EA, n=13), noneosinophilic asthmatics (NEA, n=16), and healthy controls (HC, n=15) were enrolled.
A global profile of untargeted serum metabolomics was identified with Ultra Performance Liquid Chromatography–Mass Spectrometry technique.
Results.
Multivariate analysis was performed and showed a clear distinction between EA, NEA, and HC.
A total of 18 different metabolites were recognized between the three groups based on OPLS-DA model and involved in 10 perturbed metabolic pathways.
Glycerophospholipid metabolism, retinol metabolism, and sphingolipid metabolism were identified as the most significant changed three pathways (impact > 0.1 and -log(P) > 4) between the phenotypes.
Conclusions.
We showed that the different inflammatory phenotypes of asthma involve the immune regulation, energy, and nutrients metabolism.
The clarified metabolic profile contributes to understanding the pathophysiology of asthma phenotypes and optimizing the therapeutic strategy against asthma heterogeneity.
American Psychological Association (APA)
Pang, Zhiqiang& Wang, Guoqiang& Wang, Cuizhu& Zhang, Weijie& Liu, Jinping& Wang, Fang. 2018. Serum Metabolomics Analysis of Asthma in Different Inflammatory Phenotypes: A Cross-Sectional Study in Northeast China. BioMed Research International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1125434
Modern Language Association (MLA)
Pang, Zhiqiang…[et al.]. Serum Metabolomics Analysis of Asthma in Different Inflammatory Phenotypes: A Cross-Sectional Study in Northeast China. BioMed Research International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1125434
American Medical Association (AMA)
Pang, Zhiqiang& Wang, Guoqiang& Wang, Cuizhu& Zhang, Weijie& Liu, Jinping& Wang, Fang. Serum Metabolomics Analysis of Asthma in Different Inflammatory Phenotypes: A Cross-Sectional Study in Northeast China. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1125434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125434