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Genome-Scale Metabolic Modeling of Archaea Lends Insight into Diversity of Metabolic Function
المؤلفون المشاركون
Luthey-Schulten, Zaida
Thor, ShengShee
Peterson, Joseph R.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-04
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Decades of biochemical, bioinformatic, and sequencing data are currently being systematically compiled into genome-scale metabolic reconstructions (GEMs).
Such reconstructions are knowledge-bases useful for engineering, modeling, and comparative analysis.
Here we review the fifteen GEMs of archaeal species that have been constructed to date.
They represent primarily members of the Euryarchaeota with three-quarters comprising representative of methanogens.
Unlike other reviews on GEMs, we specially focus on archaea.
We briefly review the GEM construction process and the genealogy of the archaeal models.
The major insights gained during the construction of these models are then reviewed with specific focus on novel metabolic pathway predictions and growth characteristics.
Metabolic pathway usage is discussed in the context of the composition of each organism’s biomass and their specific energy and growth requirements.
We show how the metabolic models can be used to study the evolution of metabolism in archaea.
Conservation of particular metabolic pathways can be studied by comparing reactions using the genes associated with their enzymes.
This demonstrates the utility of GEMs to evolutionary studies, far beyond their original purpose of metabolic modeling; however, much needs to be done before archaeal models are as extensively complete as those for bacteria.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Thor, ShengShee& Peterson, Joseph R.& Luthey-Schulten, Zaida. 2017. Genome-Scale Metabolic Modeling of Archaea Lends Insight into Diversity of Metabolic Function. Archaea،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1125477
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Thor, ShengShee…[et al.]. Genome-Scale Metabolic Modeling of Archaea Lends Insight into Diversity of Metabolic Function. Archaea No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1125477
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Thor, ShengShee& Peterson, Joseph R.& Luthey-Schulten, Zaida. Genome-Scale Metabolic Modeling of Archaea Lends Insight into Diversity of Metabolic Function. Archaea. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1125477
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125477
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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