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The Use of a Hypoallergenic Dermal Matrix for Wrapping in Peripheral Nerve Lesions Regeneration: Functional and Quantitative Morphological Analysis in an Experimental Animal Model
المؤلفون المشاركون
Lo Giudice, Roberto
Colonna, Michele R.
Fazio, Antonina
Costa, Alfio Luca
Galletti, Franco
Galletti, Bruno
Galletti, Cosimo
Lo Giudice, Giorgio
Dell’Aversana Orabona, Giovanni
Papalia, Igor
Geuna, Stefano
Ronchi, Giulia
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
The aim of this research was to test, in an animal model, the nerve regeneration technique with a hypoallergenic acellular dermal matrix used to wrap the microsurgical neural suture.
Materials and Methods.
Two groups of rats received the cut of limb right median nerves.
The regeneration technique considers for both groups an end-to-end nerve suture.
In the experimental group (A) was used also a wrapping protocol by a conduit of collagen matrix currently used in oral surgery.
The animals underwent functional grasping tests (at 1, 3, 5, and 7 months) and a histological and quantitative analysis of distal nerve was performed at the end of experimental time.
Result.
After seven months, the grasping test reveals functional recovery in each tested animal; this improvement is more evident in Group A.
The fibers appear well organized with restored myelin sheaths in both groups.
Group A showed a great quantity of connective tissue surrounding the nerve.
The quantitative morphology analysis in both groups shows a similar fibers density, fiber diameter, and myelin thickness.
The differences between the groups in axon mean diameter are significant.
In Group A M/d, D/d, and g-ratio is significantly higher compared to control group.
Conclusions.
Histological and functional assessments show a functional recovery of the injured nerve in the test groups, stressed by the results of the grasping tests and the meaningful increasing in fiber diameter and higher g-ratio.
Moreover, a connective tissue cuff distinguishes the distal portion of the injured nerve.
Considering the easy availability and handling of the material used in this study we can conclude that this experimental technique can be considered as a valid alternative to protect nerves in nerve wrap surgery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Colonna, Michele R.& Fazio, Antonina& Costa, Alfio Luca& Galletti, Franco& Lo Giudice, Roberto& Galletti, Bruno…[et al.]. 2019. The Use of a Hypoallergenic Dermal Matrix for Wrapping in Peripheral Nerve Lesions Regeneration: Functional and Quantitative Morphological Analysis in an Experimental Animal Model. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1125571
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Colonna, Michele R.…[et al.]. The Use of a Hypoallergenic Dermal Matrix for Wrapping in Peripheral Nerve Lesions Regeneration: Functional and Quantitative Morphological Analysis in an Experimental Animal Model. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1125571
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Colonna, Michele R.& Fazio, Antonina& Costa, Alfio Luca& Galletti, Franco& Lo Giudice, Roberto& Galletti, Bruno…[et al.]. The Use of a Hypoallergenic Dermal Matrix for Wrapping in Peripheral Nerve Lesions Regeneration: Functional and Quantitative Morphological Analysis in an Experimental Animal Model. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1125571
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125571
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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