Polymorphisms of TNF-α -308 GA and IL-8 -251 TA Genes Associated with Urothelial Carcinoma: A Case-Control Study
المؤلفون المشاركون
Huang, Yung-Kai
Huang, Chao-Yuan
Su, Chien-Tien
Wu, Chia-Chang
Shiue, Horng-Sheng
Lin, Ying-Chin
Hsueh, Yu-Mei
Pu, Yeong-Shiau
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cigarette smoking and exposure to environmental tobacco smoke are well-known risk factors for urothelial carcinoma (UC).
We conducted a hospital-based case-control study involving 287 UC cases and 574 cancer-free controls to investigate the joint effects of cigarette smoking and polymorphisms of inflammatory genes on UC risk.
Tumor necrosis factor alpha (TNF-α) -308 G/A and interleukin-8 (IL-8) -251 T/A polymorphisms were determined using a polymerase chain reaction-restriction fragment length polymorphism method.
People who had ever smoked and those who were exposed to environmental tobacco smoke had significantly increased UC odds ratios (ORs) of 1.65 and 1.68, respectively.
Participants who had smoked more than 18 pack-years had a significantly increased UC OR of 2.64.
People who had ever smoked and who carried the A/A genotype of the TNF-α -308 G/A polymorphism had a significantly higher UC OR (10.25) compared to people who had never smoked and who carried the G/G or G/A genotype.
In addition, people who had ever smoked and who carried the IL-8 -251 T/T genotype had a significantly increased UC OR (3.08) compared to people who had never smoked and who carried the T/A or A/A genotype.
In a combined analysis of three major risk factors (cumulative cigarette smoking, the TNF-α -308 A/A genotype, and the IL-8 -251 T/T genotype), subjects with any one, any two, and all three risk factors experienced significantly increased UC ORs of 1.55, 2.89, and 3.77, respectively, compared to individuals with none of the risk factors.
Conclusions.
Our results indicate that the combined effects of cumulative cigarette exposure and the TNF-α -308 A/A genotype and/or the IL-8 -251 T/T genotype on UC OR showed a significant dose-response relationship.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Chia-Chang& Huang, Yung-Kai& Huang, Chao-Yuan& Shiue, Horng-Sheng& Pu, Yeong-Shiau& Su, Chien-Tien…[et al.]. 2018. Polymorphisms of TNF-α -308 GA and IL-8 -251 TA Genes Associated with Urothelial Carcinoma: A Case-Control Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125672
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Chia-Chang…[et al.]. Polymorphisms of TNF-α -308 GA and IL-8 -251 TA Genes Associated with Urothelial Carcinoma: A Case-Control Study. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1125672
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Chia-Chang& Huang, Yung-Kai& Huang, Chao-Yuan& Shiue, Horng-Sheng& Pu, Yeong-Shiau& Su, Chien-Tien…[et al.]. Polymorphisms of TNF-α -308 GA and IL-8 -251 TA Genes Associated with Urothelial Carcinoma: A Case-Control Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125672
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125672
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر