Polymorphisms of TNF-α -308 GA and IL-8 -251 TA Genes Associated with Urothelial Carcinoma: A Case-Control Study
Joint Authors
Huang, Yung-Kai
Huang, Chao-Yuan
Su, Chien-Tien
Wu, Chia-Chang
Shiue, Horng-Sheng
Lin, Ying-Chin
Hsueh, Yu-Mei
Pu, Yeong-Shiau
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cigarette smoking and exposure to environmental tobacco smoke are well-known risk factors for urothelial carcinoma (UC).
We conducted a hospital-based case-control study involving 287 UC cases and 574 cancer-free controls to investigate the joint effects of cigarette smoking and polymorphisms of inflammatory genes on UC risk.
Tumor necrosis factor alpha (TNF-α) -308 G/A and interleukin-8 (IL-8) -251 T/A polymorphisms were determined using a polymerase chain reaction-restriction fragment length polymorphism method.
People who had ever smoked and those who were exposed to environmental tobacco smoke had significantly increased UC odds ratios (ORs) of 1.65 and 1.68, respectively.
Participants who had smoked more than 18 pack-years had a significantly increased UC OR of 2.64.
People who had ever smoked and who carried the A/A genotype of the TNF-α -308 G/A polymorphism had a significantly higher UC OR (10.25) compared to people who had never smoked and who carried the G/G or G/A genotype.
In addition, people who had ever smoked and who carried the IL-8 -251 T/T genotype had a significantly increased UC OR (3.08) compared to people who had never smoked and who carried the T/A or A/A genotype.
In a combined analysis of three major risk factors (cumulative cigarette smoking, the TNF-α -308 A/A genotype, and the IL-8 -251 T/T genotype), subjects with any one, any two, and all three risk factors experienced significantly increased UC ORs of 1.55, 2.89, and 3.77, respectively, compared to individuals with none of the risk factors.
Conclusions.
Our results indicate that the combined effects of cumulative cigarette exposure and the TNF-α -308 A/A genotype and/or the IL-8 -251 T/T genotype on UC OR showed a significant dose-response relationship.
American Psychological Association (APA)
Wu, Chia-Chang& Huang, Yung-Kai& Huang, Chao-Yuan& Shiue, Horng-Sheng& Pu, Yeong-Shiau& Su, Chien-Tien…[et al.]. 2018. Polymorphisms of TNF-α -308 GA and IL-8 -251 TA Genes Associated with Urothelial Carcinoma: A Case-Control Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125672
Modern Language Association (MLA)
Wu, Chia-Chang…[et al.]. Polymorphisms of TNF-α -308 GA and IL-8 -251 TA Genes Associated with Urothelial Carcinoma: A Case-Control Study. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1125672
American Medical Association (AMA)
Wu, Chia-Chang& Huang, Yung-Kai& Huang, Chao-Yuan& Shiue, Horng-Sheng& Pu, Yeong-Shiau& Su, Chien-Tien…[et al.]. Polymorphisms of TNF-α -308 GA and IL-8 -251 TA Genes Associated with Urothelial Carcinoma: A Case-Control Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125672
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125672