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The Role of Periostin in Capsule Formation on Silicone Implants
المؤلفون المشاركون
Chang, Hak
Park, Ji-Ung
Bae, Hahn-Sol
Son, Hye-Youn
Lee, Jung Pyo
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Although silicone implants are widely used in breast and other reconstructive surgeries, the limited biocompatibility of these materials leads to severe complications, including capsular contracture.
Here, we aimed to clarify the relationship between periostin and the process of capsule formation after in vivo implantation.
Seven-week-old wild-type (WT) C57BL/6 mice and periostin-deficient mice were used.
Round silicone implants were inserted into a subcutaneous pocket on the dorsum of the mice.
After 8 weeks, the fibrous capsule around the implant was harvested and histologically examined to estimate capsular thickness and the number of inflammatory cells.
Additionally, immunohistochemical analysis (periostin, α-SMA, and collagen type I) and western blotting (CTGF, TGF-β, VEGF, and MPO) were performed for a more detailed analysis of capsule formation.
The capsules in periostin-knockout mice (PN-KO) were significantly thinner than those in WT mice.
PN-KO mice showed significantly lower numbers of inflammatory cells than WT mice.
Fibrous tissue formation markers (α-SMA, periostin, collagen type I, and CTGF) were significantly reduced in PN-KO mice.
We also confirmed that inflammatory reaction and angiogenesis indicators (TGF-β, MPO, and VEGF) had lower expression in PN-KO mice.
Inhibition of periostin could be important for suppressing capsule formation on silicone implants after in vivo implantation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bae, Hahn-Sol& Son, Hye-Youn& Lee, Jung Pyo& Chang, Hak& Park, Ji-Ung. 2018. The Role of Periostin in Capsule Formation on Silicone Implants. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125687
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bae, Hahn-Sol…[et al.]. The Role of Periostin in Capsule Formation on Silicone Implants. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1125687
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bae, Hahn-Sol& Son, Hye-Youn& Lee, Jung Pyo& Chang, Hak& Park, Ji-Ung. The Role of Periostin in Capsule Formation on Silicone Implants. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125687
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125687
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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