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The Role of Periostin in Capsule Formation on Silicone Implants
Joint Authors
Chang, Hak
Park, Ji-Ung
Bae, Hahn-Sol
Son, Hye-Youn
Lee, Jung Pyo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Although silicone implants are widely used in breast and other reconstructive surgeries, the limited biocompatibility of these materials leads to severe complications, including capsular contracture.
Here, we aimed to clarify the relationship between periostin and the process of capsule formation after in vivo implantation.
Seven-week-old wild-type (WT) C57BL/6 mice and periostin-deficient mice were used.
Round silicone implants were inserted into a subcutaneous pocket on the dorsum of the mice.
After 8 weeks, the fibrous capsule around the implant was harvested and histologically examined to estimate capsular thickness and the number of inflammatory cells.
Additionally, immunohistochemical analysis (periostin, α-SMA, and collagen type I) and western blotting (CTGF, TGF-β, VEGF, and MPO) were performed for a more detailed analysis of capsule formation.
The capsules in periostin-knockout mice (PN-KO) were significantly thinner than those in WT mice.
PN-KO mice showed significantly lower numbers of inflammatory cells than WT mice.
Fibrous tissue formation markers (α-SMA, periostin, collagen type I, and CTGF) were significantly reduced in PN-KO mice.
We also confirmed that inflammatory reaction and angiogenesis indicators (TGF-β, MPO, and VEGF) had lower expression in PN-KO mice.
Inhibition of periostin could be important for suppressing capsule formation on silicone implants after in vivo implantation.
American Psychological Association (APA)
Bae, Hahn-Sol& Son, Hye-Youn& Lee, Jung Pyo& Chang, Hak& Park, Ji-Ung. 2018. The Role of Periostin in Capsule Formation on Silicone Implants. BioMed Research International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125687
Modern Language Association (MLA)
Bae, Hahn-Sol…[et al.]. The Role of Periostin in Capsule Formation on Silicone Implants. BioMed Research International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1125687
American Medical Association (AMA)
Bae, Hahn-Sol& Son, Hye-Youn& Lee, Jung Pyo& Chang, Hak& Park, Ji-Ung. The Role of Periostin in Capsule Formation on Silicone Implants. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1125687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125687