Apelin-13 Is an Early Promoter of Cytoskeleton and Tight Junction in Diabetic Macular Edema via PI-3KAkt and MAPKErk Signaling Pathways
المؤلفون المشاركون
Sun, Gui-Bo
Yu, Wenzhen
Bai, Yu-Jing
Li, Yang
Jiang, Yan-rong
Shi, Xuan
Chen, Li
Feng, Jing
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-04
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Diabetic macular edema is major cause of vision loss associated with diabetic retinopathy.
Breakdown of blood-retinal barrier, especially inner BRB, is an early event in pathogenesis of DR.
Apelin, an endogenous ligand of APJ, mediates angiogenesis and is involved in the development of DR.
The present study aimed to investigate effects and mechanism of apelin-13 in vascular permeability during DME.
We verified apelin-13 was upregulated in DME patients’ vitreous.
High glucose incubation led to a progressive increase of apelin-13, APJ, cytoskeleton, and tight junction proteins, including VE-Cadherin, FAK, Src, ZO-1, and occludin.
Apelin-13 promoted HRMEC proliferation and migration and phosphorylation of both cytoskeleton and tight junction under both normal and high glucose conditions.
Besides, apelin-13 activated PI-3K/Akt and MAPK/Erk signaling pathways, including PLCγ1, p38, Akt, and Erk both in HRMEC and in C57BL/6 mice.
Meanwhile, F13A performed opposite effects compared with apelin-13.
In in vivo study, apelin-13 was also upregulated in retina of db/db mice.
Taken together, apelin-13 increased biologic activity of HRMEC, as well as expression of both cytoskeleton and tight junction in DME via PI-3K/Akt and MAPK/Erk signaling pathways.
Apelin-13 as an early promoter of vascular permeability may offer a new perspective strategy in early treatment of DR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yang& Bai, Yu-Jing& Jiang, Yan-rong& Yu, Wenzhen& Shi, Xuan& Chen, Li…[et al.]. 2018. Apelin-13 Is an Early Promoter of Cytoskeleton and Tight Junction in Diabetic Macular Edema via PI-3KAkt and MAPKErk Signaling Pathways. BioMed Research International،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1125723
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yang…[et al.]. Apelin-13 Is an Early Promoter of Cytoskeleton and Tight Junction in Diabetic Macular Edema via PI-3KAkt and MAPKErk Signaling Pathways. BioMed Research International No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1125723
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yang& Bai, Yu-Jing& Jiang, Yan-rong& Yu, Wenzhen& Shi, Xuan& Chen, Li…[et al.]. Apelin-13 Is an Early Promoter of Cytoskeleton and Tight Junction in Diabetic Macular Edema via PI-3KAkt and MAPKErk Signaling Pathways. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1125723
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125723
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر