Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic
المؤلفون المشاركون
Lara-Ramírez, Edgar E.
López-Hernández, Yamilé
Rivas-Santiago, Cesar
González-Curiel, Irma
Zarazua, Sergio
Murgu, Michael
Ruiz Cardona, Alonso
Lazalde, Blanca
Vázquez, Edgar
Castañeda-Delgado, Julio Enrique
Rivas-Santiago, Bruno
Lopez, Jesús Adrián
Cervantes-Villagrana, Alberto R.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-15
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Chronic exposure to arsenic (As), whether directly through the consumption of contaminated drinking water or indirectly through the daily intake of As-contaminated food, is a health threat for more than 150 million people worldwide.
Epidemiological studies found an association between chronic consumption of As and several pathologies, the most common being cancer-related disorders.
However, As consumption has also been associated with metabolic disorders that could lead to diverse pathologies, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease, and obesity.
Here, we used ultra-performance liquid chromatography (UPLC) coupled to electrospray ionization/quadrupole time-of-flight mass spectrometry (ESI-QToF) to assess the effect of chronic intergenerational As exposure on the lipid metabolism profiles of serum from 4-month-old Wistar rats exposed to As prenatally and also during early life in drinking water (3 ppm).
Significant differences in the levels of certain identified lysophospholipids, phosphatidylcholines, and triglycerides were found between the exposed rats and the control groups, as well as between the sexes.
Significantly increased lipid oxidation determined by the malondialdehyde (MDA) method was found in exposed rats compared with controls.
Chronic intergenerational As exposure alters the rat lipidome, increases lipid oxidation, and dysregulates metabolic pathways, the factors associated with the chronic inflammation present in different diseases associated with chronic exposure to As (i.e., keratosis, Bowen’s disease, and kidney, liver, bladder, and lung cancer).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rivas-Santiago, Cesar& González-Curiel, Irma& Zarazua, Sergio& Murgu, Michael& Ruiz Cardona, Alonso& Lazalde, Blanca…[et al.]. 2019. Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic. BioMed Research International،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1125730
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rivas-Santiago, Cesar…[et al.]. Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic. BioMed Research International No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1125730
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rivas-Santiago, Cesar& González-Curiel, Irma& Zarazua, Sergio& Murgu, Michael& Ruiz Cardona, Alonso& Lazalde, Blanca…[et al.]. Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1125730
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125730
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر