Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic
Joint Authors
Lara-Ramírez, Edgar E.
López-Hernández, Yamilé
Rivas-Santiago, Cesar
González-Curiel, Irma
Zarazua, Sergio
Murgu, Michael
Ruiz Cardona, Alonso
Lazalde, Blanca
Vázquez, Edgar
Castañeda-Delgado, Julio Enrique
Rivas-Santiago, Bruno
Lopez, Jesús Adrián
Cervantes-Villagrana, Alberto R.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-15
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Chronic exposure to arsenic (As), whether directly through the consumption of contaminated drinking water or indirectly through the daily intake of As-contaminated food, is a health threat for more than 150 million people worldwide.
Epidemiological studies found an association between chronic consumption of As and several pathologies, the most common being cancer-related disorders.
However, As consumption has also been associated with metabolic disorders that could lead to diverse pathologies, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease, and obesity.
Here, we used ultra-performance liquid chromatography (UPLC) coupled to electrospray ionization/quadrupole time-of-flight mass spectrometry (ESI-QToF) to assess the effect of chronic intergenerational As exposure on the lipid metabolism profiles of serum from 4-month-old Wistar rats exposed to As prenatally and also during early life in drinking water (3 ppm).
Significant differences in the levels of certain identified lysophospholipids, phosphatidylcholines, and triglycerides were found between the exposed rats and the control groups, as well as between the sexes.
Significantly increased lipid oxidation determined by the malondialdehyde (MDA) method was found in exposed rats compared with controls.
Chronic intergenerational As exposure alters the rat lipidome, increases lipid oxidation, and dysregulates metabolic pathways, the factors associated with the chronic inflammation present in different diseases associated with chronic exposure to As (i.e., keratosis, Bowen’s disease, and kidney, liver, bladder, and lung cancer).
American Psychological Association (APA)
Rivas-Santiago, Cesar& González-Curiel, Irma& Zarazua, Sergio& Murgu, Michael& Ruiz Cardona, Alonso& Lazalde, Blanca…[et al.]. 2019. Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic. BioMed Research International،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1125730
Modern Language Association (MLA)
Rivas-Santiago, Cesar…[et al.]. Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic. BioMed Research International No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1125730
American Medical Association (AMA)
Rivas-Santiago, Cesar& González-Curiel, Irma& Zarazua, Sergio& Murgu, Michael& Ruiz Cardona, Alonso& Lazalde, Blanca…[et al.]. Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1125730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125730