Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit
المؤلفون المشاركون
Sánchez-Ramírez, Blanca
Levario-Carrillo, Margarita
Ballesteros-Guzmán, Ana Karen
Carrasco-Legleu, Claudia E.
Chávez-Corral, Dora Virginia
Mariñelarena-Carrillo, Edgar Omar
Guerrero-Salgado, Fabiola
Reza-López, Sandra Alicia
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Obesity and pregnancy increase levels of maternal oxidative stress (OS).
However, little is known about the maternal, placental, and neonatal OS status.
Objective.
To analyze the relation between prepregnancy obesity and the expression of OS markers and antioxidant capacity in the fetomaternal unit and their association with dietary intake.
Methods.
This cross-sectional study included 33 women with singleton, noncomplicated pregnancies.
Two groups were formed: women with prepregnancy body mass index (pBMI) within normal range (18.5-24.9 kg/m2, n = 18) and women with pBMI ≥ 30 kg/m2, suggestive of obesity (n = 15).
Dietary and clinical information was obtained by questionnaire and from clinical records.
Total antioxidant capacity (TAC) and malondialdehyde (MDA) concentration were measured on maternal and cord serum by colorimetric techniques, and placental expression of glutathione peroxidase 4 (GPx4) was measured by immunohistochemistry.
Results.
Placental GPx4 expression was lower in the group with pBMI suggestive of obesity than in the normal weight group (ß = -0.08, p = 0.03, adjusted for gestational age and magnesium intake).
Concentrations of TAC and MDA in maternal and cord blood were not statistically different between groups (p>0.05).
Cord MDA concentration was related to maternal MDA concentration (ß = 0.40, p < 0.01), vitamin A intake (tertile 2: ß = -0.04, p = 0.40, tertile 3: ß = 0.13, p = 0.03, vs tertile 1), and placental GPx4 expression (ß = -0.09, p = 0.02).
Conclusion.
Prepregnancy obesity is associated with a decrease in GPx4 expression in the placenta, which is related to OS in the newborn.
The influence of micronutrient intake on OS biomarkers highlights the importance of nutritional assessment during pregnancy and adequate prenatal care.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ballesteros-Guzmán, Ana Karen& Carrasco-Legleu, Claudia E.& Levario-Carrillo, Margarita& Chávez-Corral, Dora Virginia& Sánchez-Ramírez, Blanca& Mariñelarena-Carrillo, Edgar Omar…[et al.]. 2019. Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1125795
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ballesteros-Guzmán, Ana Karen…[et al.]. Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1125795
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ballesteros-Guzmán, Ana Karen& Carrasco-Legleu, Claudia E.& Levario-Carrillo, Margarita& Chávez-Corral, Dora Virginia& Sánchez-Ramírez, Blanca& Mariñelarena-Carrillo, Edgar Omar…[et al.]. Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1125795
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125795
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر