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Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit
Joint Authors
Sánchez-Ramírez, Blanca
Levario-Carrillo, Margarita
Ballesteros-Guzmán, Ana Karen
Carrasco-Legleu, Claudia E.
Chávez-Corral, Dora Virginia
Mariñelarena-Carrillo, Edgar Omar
Guerrero-Salgado, Fabiola
Reza-López, Sandra Alicia
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Obesity and pregnancy increase levels of maternal oxidative stress (OS).
However, little is known about the maternal, placental, and neonatal OS status.
Objective.
To analyze the relation between prepregnancy obesity and the expression of OS markers and antioxidant capacity in the fetomaternal unit and their association with dietary intake.
Methods.
This cross-sectional study included 33 women with singleton, noncomplicated pregnancies.
Two groups were formed: women with prepregnancy body mass index (pBMI) within normal range (18.5-24.9 kg/m2, n = 18) and women with pBMI ≥ 30 kg/m2, suggestive of obesity (n = 15).
Dietary and clinical information was obtained by questionnaire and from clinical records.
Total antioxidant capacity (TAC) and malondialdehyde (MDA) concentration were measured on maternal and cord serum by colorimetric techniques, and placental expression of glutathione peroxidase 4 (GPx4) was measured by immunohistochemistry.
Results.
Placental GPx4 expression was lower in the group with pBMI suggestive of obesity than in the normal weight group (ß = -0.08, p = 0.03, adjusted for gestational age and magnesium intake).
Concentrations of TAC and MDA in maternal and cord blood were not statistically different between groups (p>0.05).
Cord MDA concentration was related to maternal MDA concentration (ß = 0.40, p < 0.01), vitamin A intake (tertile 2: ß = -0.04, p = 0.40, tertile 3: ß = 0.13, p = 0.03, vs tertile 1), and placental GPx4 expression (ß = -0.09, p = 0.02).
Conclusion.
Prepregnancy obesity is associated with a decrease in GPx4 expression in the placenta, which is related to OS in the newborn.
The influence of micronutrient intake on OS biomarkers highlights the importance of nutritional assessment during pregnancy and adequate prenatal care.
American Psychological Association (APA)
Ballesteros-Guzmán, Ana Karen& Carrasco-Legleu, Claudia E.& Levario-Carrillo, Margarita& Chávez-Corral, Dora Virginia& Sánchez-Ramírez, Blanca& Mariñelarena-Carrillo, Edgar Omar…[et al.]. 2019. Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit. BioMed Research International،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1125795
Modern Language Association (MLA)
Ballesteros-Guzmán, Ana Karen…[et al.]. Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit. BioMed Research International No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1125795
American Medical Association (AMA)
Ballesteros-Guzmán, Ana Karen& Carrasco-Legleu, Claudia E.& Levario-Carrillo, Margarita& Chávez-Corral, Dora Virginia& Sánchez-Ramírez, Blanca& Mariñelarena-Carrillo, Edgar Omar…[et al.]. Prepregnancy Obesity, Maternal Dietary Intake, and Oxidative Stress Biomarkers in the Fetomaternal Unit. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1125795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1125795